{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:02:32Z","timestamp":1790791352937,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University Research Projects (Unicam- FAR) grant to MGS","award":["BVI000014"],"award-info":[{"award-number":["BVI000014"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The p62 (also named sequestosome1\/SQSTM1) is multidomain and multifunctional protein associated with several physiological and pathological conditions. A number of studies evidenced an involvement of p62 on the disruptive bone scenarios due to its participation in the inflammatory\/osteoclastogenic pathways. However, so far, information regarding the function of p62 in the fine\u2010tuned processes underpinning the bone physiology are not well\u2010defined and are sometime discordant. We, previously, demonstrated that the intramuscular administration of a plasmid coding for p62 was able to contrast bone loss in a mouse model of osteopenia. Here, in vitro findings showed that the p62 overexpression in murine osteoblasts precursors enhanced their maturation while the p62 depletion by a specific siRNA, decreased osteoblasts differentiation. Consistently, the activity of osteoblasts from p62<jats:sup>\u2212\/\u2212<\/jats:sup> mice was reduced compared with wild\u2010type. Also, morphometric analyses of bone from p62 knockout mice revealed a pathological phenotype characterized by a lower turnover that could be explained by the poor Runx2 protein synthesis in absence of p62. Furthermore, we demonstrated that the parathyroid hormone (PTH) regulates p62 expression and that the osteogenic effects of this hormone were totally abrogated in osteoblasts from p62\u2010deficient mice. Therefore, these findings, for the first time, highlight the important role of p62 both for the basal and for PTH\u2010stimulated bone remodeling.<\/jats:p>","DOI":"10.1002\/jcp.29654","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T11:46:08Z","timestamp":1582717568000},"page":"7516-7529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Loss of p62 impairs bone turnover and inhibits PTH\u2010induced osteogenesis"],"prefix":"10.1002","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7809-3601","authenticated-orcid":false,"given":"Dimitrios","family":"Agas","sequence":"first","affiliation":[{"name":"School of Biosciences and Veterinary Medicine University of Camerino Macerata Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Amaroli","sequence":"additional","affiliation":[{"name":"Department of Surgical and Diagnostic Sciences, Laser Therapy Center University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Lacava","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine University of Camerino Macerata Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yanagawa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0838-5748","authenticated-orcid":false,"given":"Maria Giovanna","family":"Sabbieti","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine University of Camerino Macerata Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.76.6.1617"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00290.2013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.12.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2011.624631"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1728-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.483"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05315.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02040"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021388"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1954"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20323"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-2730000003399"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.2.5498"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00403-9"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2005.09.016"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302457200"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008200390152188"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208494200"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.17.6222-6233.2002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn266"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650070110"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1668"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.0301226"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0014"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.035"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80258-5"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2002-0225"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28299"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(95)00443-2"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705194200"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070121"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.4232"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21187"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8641"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.023"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2012.02.008"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401823"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21589"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-009-9316-6"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2014.07.037"},{"key":"e_1_2_9_42_1","first-page":"689","article-title":"The role of the bone marrow stromal compartment in the hematopoietic response to microbial infections","volume":"7","author":"Nombela\u2010Arrieta C.","year":"2016","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.159"},{"key":"e_1_2_9_44_1","first-page":"552","article-title":"PTH and stem cells","volume":"34","author":"Ohishi M.","year":"2011","journal-title":"Journal of Endocrinological Investigation"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80259-7"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080803"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2884"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21471"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21661"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40778-017-0091-7"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/gew039"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2062"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-110-2-506"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.05.004"},{"key":"e_1_2_9_55_1","first-page":"297","article-title":"The estrogen 17beta\u2010estradiol and phytoestrogen genistein mediate differential effects on osteoblastic NF\u2010kappaB activity","volume":"23","author":"Yamaguchi M.","year":"2009","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2108"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1663"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002449"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.29654","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.29654","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.29654","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.29654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T05:17:39Z","timestamp":1740892659000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.29654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,26]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/jcp.29654"],"URL":"https:\/\/doi.org\/10.1002\/jcp.29654","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,26]]},"assertion":[{"value":"2019-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}