{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:27:28Z","timestamp":1774978048162,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1A2C1004131"],"award-info":[{"award-number":["2020R1A2C1004131"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017M3A9G8083382"],"award-info":[{"award-number":["2017M3A9G8083382"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As antithrombotic effects of maslinic acid (MA) have not yet been studied, MA\u2010mediated downregulation of coagulation factor Xa (FXa) and platelet aggregation was studied. We show that MA inhibited the enzymatic activity of FXa and platelet aggregation, induced by adenosine diphosphate (ADP) and a thromboxane A<jats:sub>2<\/jats:sub> (TXA<jats:sub>2<\/jats:sub>) analog, U46619 with a similar antithrombotic efficacy to rivaroxaban, a direct FXa inhibitor used as a positive control. Mechanistically, MA suppressed U46619\u2010 or ADP\u2010induced phosphorylation of myristoylated alanine\u2010rich C kinase substrate, and the expression of P\u2010selectin, and activated PAC\u20101 in platelets. MA increased generation of nitric oxide, but downregulated excessive secretion of endothelin\u20101 in ADP\u2010 or U46619\u2010treated human umbilical vein endothelial cells. In arterial and pulmonary thrombosis mouse model, MA showed prominent anticoagulant and antithrombotic effects. Our data suggest MA as a candidate molecule for a new class of drugs targeting anti\u2010FXa and antiplatelet.<\/jats:p>","DOI":"10.1002\/jcp.29749","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T05:28:05Z","timestamp":1588310885000},"page":"9445-9456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Novel factor Xa inhibitor, maslinic acid, with antiplatelet aggregation activity"],"prefix":"10.1002","volume":"235","author":[{"given":"Kyung\u2010Min","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Plant Biosciences, School of Applied BioSciences, College of Agriculture and Life Science Kyungpook National University  Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaehong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine Gachon University  Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon\u2010Chang","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, CMRI, School of Medicine Kyungpook National University  Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5756-9367","authenticated-orcid":false,"given":"Jong\u2010Sup","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi\u2010Omics based Creative Drug Research Team, Kyungpook National University  Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05032.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-006-5579-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.63.070194.001135"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200000002-00013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02225-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/np900749b"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)33551-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2293"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.3.894.003k15_894_902"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1272544"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(91)82294-9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2017.1384811"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.08.015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)83641-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2018.4268"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.09.175"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.157479"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12257-018-0434-y"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e318284056a"},{"issue":"21","key":"e_1_2_8_21_1","first-page":"2802","article-title":"[Antiplatelet therapy after aspirin\u2010induced upper gastrointestinal bleeding]","volume":"126","author":"Johansen M.","year":"2006","journal-title":"Tidsskrift for den Norske Laegeforening"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.10.007"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.11.057"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.198242"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24163"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2019.52.4.175"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2018.4230"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-014-0410-9"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12257-019-0096-4"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.04.012"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.7b00826"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1669477"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12257-018-0407-1"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.10.124"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules190811538"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.16.1931"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08220.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-39698"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-016-1350-7"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi971147e"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248415578172"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.202978"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315099"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-199607000-00003"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.07.033"},{"issue":"11","key":"e_1_2_8_46_1","first-page":"1227","article-title":"Platelets in atherothrombosis","volume":"8","author":"Ruggeri Z. M.","year":"2002","journal-title":"Nature Medicine (New York, NY, United States)"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310640"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003950070048"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739680590925682"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2006.036"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07819.x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-967173"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/332411a0"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.29749","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.29749","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.29749","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.29749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T12:47:11Z","timestamp":1748350031000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.29749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,30]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/jcp.29749"],"URL":"https:\/\/doi.org\/10.1002\/jcp.29749","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,30]]},"assertion":[{"value":"2020-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}