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Endogenous H<jats:sub>2<\/jats:sub>S is produced mainly by three endogenous enzymes: cystathionine \u03b2\u2010synthase, cystathionine \u03b3\u2010lyase, and 3\u2010mercaptopyruvate sulfur transferase. Numerous studies have shown that H<jats:sub>2<\/jats:sub>S has a significant protective role in myocardial ischemia. The mechanisms by which H<jats:sub>2<\/jats:sub>S affords cardioprotection include the antifibrotic and antiapoptotic effects, regulation of ion channels, protection of mitochondria, reduction of oxidative stress and inflammatory response, regulation of microRNA expression, and promotion of angiogenesis. Amplification of NO\u2010 and CO\u2010mediated signaling through crosstalk between H<jats:sub>2<\/jats:sub>S, NO, and CO may also contribute to the cardioprotective effect. Exogenous H<jats:sub>2<\/jats:sub>S donors are expected to become effective drugs for the treatment of cardiovascular diseases. This review article focuses on the protective mechanisms and potential therapeutic applications of H<jats:sub>2<\/jats:sub>S in myocardial ischemia.<\/jats:p>","DOI":"10.1002\/jcp.29761","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T05:25:31Z","timestamp":1592285131000},"page":"9059-9070","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Protective mechanisms of hydrogen sulfide in myocardial ischemia"],"prefix":"10.1002","volume":"235","author":[{"given":"Yuqi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0736-3651","authenticated-orcid":false,"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.069"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000012702.90501.8D"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00888"},{"issue":"1","key":"e_1_2_10_6_1","first-page":"1","article-title":"Garlic: A review of potential therapeutic effects","volume":"4","author":"Bayan L.","year":"2014","journal-title":"Avicenna Journal of Phytomedicine"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705710104"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv129"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.208066"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm800956g"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.209783"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.05.026"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.199919"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.296.5573.1655"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-007-0011-8"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.116.235119"},{"key":"e_1_2_10_17_1","first-page":"129","article-title":"Neuroprotective effects of hydrogen sulfide and the underlying signaling pathways","volume":"26","author":"Chen W. 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