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So far, there are no specific treatments for patients with coronavirus disease\u201019 (COVID\u201019), and the treatments available today are based on previous experience with similar viruses such as severe acute respiratory syndrome\u2010related coronavirus (SARS\u2010CoV), Middle East respiratory syndrome coronavirus (MERS\u2010CoV), and Influenza virus. In this article, we have tried to reach a therapeutic window of drugs available to patients with COVID\u201019. Cathepsin L is required for entry of the 2019\u2010nCoV virus into the cell as target teicoplanin inhibits virus replication. Angiotensin\u2010converting\u2010enzyme 2 (ACE2) in soluble form as a recombinant protein can prevent the spread of coronavirus by restricting binding and entry. In patients with COVID\u201019, hydroxychloroquine decreases the inflammatory response and cytokine storm, but overdose causes toxicity and mortality. Neuraminidase inhibitors such as oseltamivir, peramivir, and zanamivir are invalid for 2019\u2010nCoV and are not recommended for treatment but protease inhibitors such as lopinavir\/ritonavir (LPV\/r) inhibit the progression of MERS\u2010CoV disease and can be useful for patients of COVID\u201019 and, in combination with Arbidol, has a direct antiviral effect on early replication of SARS\u2010CoV. Ribavirin reduces hemoglobin concentrations in respiratory patients, and remdesivir improves respiratory symptoms. Use of ribavirin in combination with LPV\/r in patients with SARS\u2010CoV reduces acute respiratory distress syndrome and mortality, which has a significant protective effect with the addition of corticosteroids. Favipiravir increases clinical recovery and reduces respiratory problems and has a stronger antiviral effect than LPV\/r. currently, appropriate treatment for patients with COVID\u201019 is an ACE2 inhibitor and a clinical problem reducing agent such as favipiravir in addition to hydroxychloroquine and corticosteroids.<\/jats:p>","DOI":"10.1002\/jcp.29785","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T05:28:23Z","timestamp":1589261303000},"page":"9133-9142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["A global treatments for coronaviruses including COVID\u201019"],"prefix":"10.1002","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9889-2195","authenticated-orcid":false,"given":"Bahman","family":"Yousefi","sequence":"first","affiliation":[{"name":"Department of Immunology Semnan University of Medical Sciences  Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeid","family":"Valizadeh","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Virology Semnan University of Medical Sciences  Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Ghaffari","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Virology Semnan University of Medical Sciences  Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azadeh","family":"Vahedi","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Virology Semnan University of Medical Sciences  Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Karbalaei","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Virology School of Medicine, Jiroft University of Medical Sciences  Jiroft Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5118-678X","authenticated-orcid":false,"given":"Majid","family":"Eslami","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Virology Semnan University of Medical Sciences  Semnan Iran"},{"name":"Cancer Research Center, Semnan University of Medical Sciences  Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/656316"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1993.tb00652.x"},{"issue":"2","key":"e_1_2_7_4_1","first-page":"4","article-title":"The flu\u2026and you","volume":"75","author":"Andrews N.","year":"2006","journal-title":"The Dental Assistant"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201706-1172OC"},{"key":"e_1_2_7_6_1","first-page":"A6067","article-title":"Effect of ribavirin and interferon on the outcome of critically Ill patients with MERS","volume":"195","author":"Arabi Y. 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