{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:31:53Z","timestamp":1789612313674,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572094"],"award-info":[{"award-number":["81572094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702155"],"award-info":[{"award-number":["81702155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Glucocorticoid\u2010induced osteonecrosis of the femoral head (GIOFH) is one of the most common complications of glucocorticoid administration. By chelating Fe\n                    <jats:sup>2+<\/jats:sup>\n                    , desferoxamine (DFO) was reported to be able to activate the HIF\u20101\u03b1\/VEGF pathway and promote angiogenesis. In the present study, we examined whether DFO administration could promote angiogenesis and bone repair in GIOFH. GIOFH was induced in rats by methylprednisolone in combination with lipopolysaccharide. Bone repair was assessed by histologic analysis and microcomputed tomography (micro\u2010CT). Vascularization was assessed by Microfil perfusion and micro\u2010CT analysis. Immunohistochemical staining was performed to analyze the expression of HIF\u20101\u03b1, VEGF, and CD31. Our in vivo study revealed that DFO increased HIF\u20101\u03b1\/VEGF expression and promoted angiogenesis and osteogenesis in GIOFH. Moreover, our in vitro study revealed that DFO restored dexamethone\u2010induced HIF\u20101\u03b1 downregulation and angiogenesis inhibition. Besides, our in vitro study also demonstrated that DFO could protect bone marrow\u2010derived stem cells from dexamethone\u2010induced apoptosis and mitochondrial dysfunction by promoting mitophagy and mitochondrial fission. In summary, our data provided useful information for the development of novel therapeutics for management of GIOFH.\n                  <\/jats:p>","DOI":"10.1002\/jcp.29799","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T09:29:15Z","timestamp":1590053355000},"page":"9864-9875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Desferoxamine protects against glucocorticoid\u2010induced osteonecrosis of the femoral head via activating HIF\u20101\u03b1 expression"],"prefix":"10.1002","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6916-4204","authenticated-orcid":false,"given":"Xingzhi","family":"Jing","sequence":"first","affiliation":[{"name":"Department of Spine Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong 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