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However, the pathology of these diseases is not well known, leading to an inability to find an appropriate therapeutic approach to delay occurrence or slow many neurodegenerative diseases' development. The accessibility of induced pluripotent stem cells (iPSCs) in mimicking the phenotypes of various late\u2010onset neurodegenerative diseases presents a novel strategy for in vitro disease modeling. The iPSCs provide a valuable and well\u2010identified resource to clarify neurodegenerative disease mechanisms, as well as prepare a promising human stem cell platform for drug screening. Undoubtedly, neurodegenerative disease modeling using iPSCs has established innovative opportunities for both mechanistic types of research and recognition of novel disease treatments. Most important, the iPSCs have been considered as a novel autologous cell origin for cell\u2010based therapy of neurodegenerative diseases following differentiation to varied types of neural lineage cells (e.g. GABAergic neurons, dopamine neurons, cortical neurons, and motor neurons). In this review, we summarize iPSC\u2010based disease modeling in neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and Huntington's disease. Moreover, we discuss the efficacy of cell\u2010replacement therapies for neurodegenerative disease.<\/jats:p>","DOI":"10.1002\/jcp.29800","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T13:21:01Z","timestamp":1590067261000},"page":"9166-9184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Induced pluripotent stem cells (iPSCs) as game\u2010changing tools in the treatment of neurodegenerative disease: Mirage or reality?"],"prefix":"10.1002","volume":"235","author":[{"given":"Niloufar","family":"Yousefi","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology Pasteur Instittableute of Iran  Tehran Iran"},{"name":"Stem Cell and Regenerative Medicine Center Tehran University of Medical Sciences  Tehran 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