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Herein, the functions and mechanisms of miR\u201034a\/c in caprine endometrial epithelial cell (CEEC) apoptosis and RE establishment were investigated. miR\u201034a\/c downregulated the expression level of centrosomal protein 55 (<jats:italic>CEP55<\/jats:italic>) and were sponged by circRNA8073 (circ\u20108073), thereby exhibiting a negative interaction in CEEC. miR\u201034a\/c induced CEEC apoptosis by targeting circ\u20108073\/CEP55 through the regulation of the RAS\/RAF\/MEK\/ERK and phosphoitide 3\u2010kinase (PI3K)\/protein kinase B (AKT)\/mammalian target of rapamycin (mTOR) pathways. Positive and negative feedback loops and cross\u2010talk were documented between the RAS\/RAF\/MEK\/ERK and PI3K\/AKT\/mTOR pathways. miR\u201034a\/c regulated the levels of RE marker genes, including forkhead box M1, vascular endothelial growth factor, and osteopontin (<jats:italic>OPN<\/jats:italic>). These results suggest that miR\u201034a\/c not only induce CEEC apoptosis by binding to circ\u20108073 and <jats:italic>CEP55<\/jats:italic> via the RAS\/RAF\/MEK\/ERK and PI3K\/AKT\/mTOR pathways, but may also regulate RE establishment in dairy goats.<\/jats:p>","DOI":"10.1002\/jcp.29821","type":"journal-article","created":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T15:16:11Z","timestamp":1590938171000},"page":"10051-10067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["miR\u201034a\/c induce caprine endometrial epithelial cell apoptosis by regulating circ\u20108073\/<i>CEP55<\/i> via the <i>RAS\/RAF\/MEK\/ERK<\/i> and <i>PI3K\/AKT\/mTOR<\/i> pathways"],"prefix":"10.1002","volume":"235","author":[{"given":"Xiaorui","family":"Liu","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichun","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuzeng","family":"Cui","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicheng","family":"Che","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling Shaanxi 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