{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:46:33Z","timestamp":1790462793361,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Congenital Malformations Research Center, Research and the Technology Department of Golestan University of Medical Sciences, Gorgan, Iran","award":["950616118"],"award-info":[{"award-number":["950616118"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Eye color is determined\u00a0as a polymorphism and polygenic trait. Brown is the most common eye color in the world, accounting for about 79%, blue eye color for about 8\u201310%, hazel for 5%, and green for 2%. Rare\u2010colored eyes include gray and red\/violet. Different factors are involved in determining eye color. The two most important factors are the iris pigment and the way light is scattered from the iris. Gene expression determines the iris pigmentation and how much melanin is present in the eye, which is the number of melanin subunits that identify\u00a0eye color. The genes involved in the pigmentation of single\u2010nucleotide polymorphism (SNP) have a significant role; and even some genes are included only in the eye color through SNP. MicroRNAs also affect melanocyte synthesis, which is usually affected by the downregulation of essential genes involved in pigmentation. In this study, we assess\u00a0the biochemical pathways of melanin synthesis, and the role of each gene in this pathway also has\u00a0been examined in the signaling pathway that stimulates melanin synthesis.<\/jats:p>","DOI":"10.1002\/jcp.29824","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T05:38:30Z","timestamp":1591162710000},"page":"8972-8982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Molecular and biochemical mechanisms of human iris color: A comprehensive review"],"prefix":"10.1002","volume":"235","author":[{"given":"Saeed","family":"Dorgaleleh","sequence":"first","affiliation":[{"name":"Student Research Committee Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Naghipoor","sequence":"additional","affiliation":[{"name":"Student Research Committee Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Barahouie","sequence":"additional","affiliation":[{"name":"Student Research Committee Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzad","family":"Dastaviz","sequence":"additional","affiliation":[{"name":"Student Research Committee Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7037-5084","authenticated-orcid":false,"given":"Morteza","family":"Oladnabi","sequence":"additional","affiliation":[{"name":"Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences  Gorgan Iran"},{"name":"Stem Cell Research Center, Golestan University of Medical Sciences  Gorgan Iran"},{"name":"Department of Medical Genetics, School of Advanced Technologies in Medicine Ischemic Disorders Research Center, Golestan University of Medical Sciences  Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600108113"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.037168"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.167"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705739114"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12393"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071144"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.266"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2016.04.012"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23880"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2016.12.013"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/165.4.2071"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2011.01.006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.28865"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5812\/compreped.66099"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/skinbio.2011.4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.09.039"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsigen.2019.01.001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.10.003"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.115"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-003-0998-1"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000934"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12225"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.12.030"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008385"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12346"},{"key":"e_1_2_9_27_1","unstructured":"National Center for Biotechnology Information (NCBI). (2019a). ASIP \u0101gouti signaling protein [Homo sapiens (human)]."},{"key":"e_1_2_9_28_1","unstructured":"National Center for Biotechnology Information (NCBI). (2019b). DCT dopachrome tautomerase [Homo sapiens (human)]."},{"key":"e_1_2_9_29_1","unstructured":"National Center for Biotechnology Information (NCBI). (2019c). HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Homo sapiens (human)]."},{"key":"e_1_2_9_30_1","unstructured":"National Center for Biotechnology Information (NCBI). (2019d). IRF4 interferon regulatory factor 4 [Homo sapiens (human)]."},{"key":"e_1_2_9_31_1","unstructured":"National Center for Biotechnology Information (NCBI). (2019e). KITLG KIT ligand [Homo sapiens (human)]."},{"key":"e_1_2_9_32_1","unstructured":"National Center for Biotechnology Information (NCBI). (2019f). PMEL premelanosome protein [Homo sapiens (human)]."},{"key":"e_1_2_9_33_1","unstructured":"National Center for Biotechnology Information (NCBI). (2019g). SH3BP4 SH3 domain binding protein 4 [Homo sapiens (human)]."},{"key":"e_1_2_9_34_1","unstructured":"National Center for Biotechnology Information (NCBI). (2019h). SLC24A5 solute carrier family 24 member 5 [Homo sapiens (human)]."},{"key":"e_1_2_9_35_1","unstructured":"National Center for Biotechnology Information (NCBI). (2019i). SLC45A2 solute carrier family 45 member 2 [Homo sapiens (human)]."},{"key":"e_1_2_9_36_1","unstructured":"National Center for Biotechnology Information (NCBI). (2019j). TPCN2 two pore segment channel 2 [Homo sapiens (human)]."},{"key":"e_1_2_9_37_1","unstructured":"National Center for Biotechnology Information (NCBI). (2019k). TYR tyrosinase [Homo sapiens (human)]."},{"key":"e_1_2_9_38_1","unstructured":"National Center for Biotechnology Information (NCBI). (2019l). TYRP1 tyrosinase related protein 1 [Homo sapiens (human)]."},{"key":"e_1_2_9_39_1","unstructured":"National Center for Biotechnology Information (NCBI). (2019m). OCA2 melanosomal transmembrane protein [Homo sapiens (human)]."},{"key":"e_1_2_9_40_1","unstructured":"National Center for Biotechnology Information (NCBI). (2019n). MC1R melanocortin 1 receptor [Homo sapiens (human)]."},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.310"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2005.00299.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2017.09.004"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2011.38"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.022"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10492"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.231"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2002.030401.x"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13713"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2004.06.010"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2009.00606.x"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.13"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.07.012"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46529-6"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12210"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2mb25228g"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.49"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00268.x"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2016.00095"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.01.060"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00134.x"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.29824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.29824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.29824","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.29824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:30:36Z","timestamp":1748352636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.29824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,2]]},"references-count":60,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/jcp.29824"],"URL":"https:\/\/doi.org\/10.1002\/jcp.29824","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,2]]},"assertion":[{"value":"2020-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}