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Maresin 1 (MaR1) is a specialized proresolving mediator produced during the resolution of inflammation. We determined if MaR1 stimulates mucin secretion and signaling pathways used. Cultured rat conjunctival goblet cells were used to measure the increase in intracellular Ca<jats:sup>2+<\/jats:sup> ([Ca<jats:sup>2<\/jats:sup><jats:sup>+<\/jats:sup>]<jats:sub>i<\/jats:sub>) concentration and mucin secretion. MaR1\u2010increased [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> and secretion were blocked by inhibitors of phospholipase C, protein kinase C, Ca<jats:sup>2+<\/jats:sup>\/calmodulin\u2010dependent protein kinase II, and extracellular\u2010regulated kinase 1\/2. MaR1 added before addition of histamine counterregulated histamine\u2010stimulated increase in [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> and secretion. We conclude that MaR1 likely has two actions in conjunctival goblet cells: first, maintaining optimal tear film mucin levels by increasing [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> and stimulating mucin secretion in health and, second, attenuating the increase in [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> and overproduction of mucin secretion by counterregulating the effect of histamine as occurs in ocular allergy.<\/jats:p>","DOI":"10.1002\/jcp.29846","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T14:10:50Z","timestamp":1591625450000},"page":"340-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Maresin 1, a specialized proresolving mediator, stimulates intracellular [Ca<sup>2+<\/sup>] and secretion in conjunctival goblet cells"],"prefix":"10.1002","volume":"236","author":[{"given":"Markus 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