{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T03:18:55Z","timestamp":1785467935352,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["60234"],"award-info":[{"award-number":["60234"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nonalcoholic fatty liver disease (NAFLD) is one of the most common noncommunicable diseases worldwide. The present study aimed to investigate the effects of oleoylethanolamide (OEA) supplementation combined with calorie restriction on inflammation, body composition, and hepatic fibrosis among obese patients with NAFLD. In this 12\u2010week randomized clinical trial, 76 obese patients newly diagnosed with NAFLD were randomly allocated into either OEA or placebo group. The weight\u2010loss diet was also designed for both groups. Pre\u2010 and postintervention messenger RNA expression levels of the transcription factor nuclear factor\u2010\u03baB (NF\u2010\u03baB), interleukin\u20106 (IL\u20106) and IL\u201010, body composition, and NAFLD fibrosis score were assessed. At the end of the study, the OEA group showed lower NF\u2010\u03baB and IL\u20106 expression levels compared to the placebo (<jats:italic>p\u2009<\/jats:italic>&lt;\u2009.01). However, IL\u201010 expression level was approximately twofold higher in the OEA group compared to the placebo group (<jats:italic>p\u2009<\/jats:italic>=\u2009.008). A significant reduction was observed in the fat mass of the OEA group compared to the placebo (<jats:italic>p<\/jats:italic>\u2009=\u2009.044) postintervention. In addition, OEA supplementation led to a significant increase in fat\u2010free mass in the OEA group compared to the placebo (<jats:italic>p\u2009<\/jats:italic>=\u2009.032). A remarkable increase was observed in resting metabolic rate (RMR) in the OEA group (<jats:italic>p<\/jats:italic>\u2009=\u2009.009); however, it was not found in the placebo group. There were no significant between\u2010group differences in RMR postintervention. In addition, no significant within\u2010and between\u2010group differences were observed in the NAFLD fibrosis score at the end of the trial. Treatment with OEA along with weight\u2010loss intervention could significantly improve inflammation and body composition in patients with NAFLD.<\/jats:p>","DOI":"10.1002\/jcp.29870","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T05:33:35Z","timestamp":1592890415000},"page":"417-426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Expression of NF\u2010\u03baB, IL\u20106, and IL\u201010 genes, body composition, and hepatic fibrosis in obese patients with NAFLD\u2014Combined effects of oleoylethanolamide supplementation and calorie restriction: A triple\u2010blind randomized controlled clinical trial"],"prefix":"10.1002","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4795-1757","authenticated-orcid":false,"given":"Helda","family":"Tutunchi","sequence":"first","affiliation":[{"name":"Student Research Committee, Nutrition Research Center, School of Nutrition and Food Sciences Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Department of Clinical Nutrition, Nutrition Research Center, School of Nutrition and Food Sciences Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1058-1481","authenticated-orcid":false,"given":"Alireza","family":"Ostadrahimi","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Nutrition Research Center, School of Nutrition and Food Sciences Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6658-2918","authenticated-orcid":false,"given":"Maryam","family":"Saghafi\u2010Asl","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Nutrition Research Center, School of Nutrition and Food Sciences Tabriz University of Medical Sciences  Tabriz 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