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Previously, we demonstrated that bobby sox homolog (Bbx) regulates odontoblast differentiation of human dental pulp stem cells. Here, we generated <jats:italic>Bbx<\/jats:italic> knockout (<jats:italic>Bbx<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>) mice to address the functional role of Bbx in tooth formation. During tooth development, <jats:italic>Bbx<\/jats:italic> was expressed in both dental epithelium and mesenchyme. However, molar and incisor morphology in <jats:italic>Bbx<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice at postnatal Day 0 (P0) exhibited no prominent abnormalities compared with their wild\u2010type (<jats:italic>Bbx<\/jats:italic><jats:sup>+\/+<\/jats:sup>) littermates. Until P28, the crown morphology in <jats:italic>Bbx<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice was not distinctively different from <jats:italic>Bbx<\/jats:italic><jats:sup>+\/+<\/jats:sup> littermates. Meanwhile, the length of the mandibular base in <jats:italic>Bbx<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice was notably less at P28. Compared with <jats:italic>Bbx<\/jats:italic><jats:sup>+\/+<\/jats:sup> mice, the mesial and distal root lengths of the first molar were reduced by 21.33% and 16.28% at P14 and 16.28% and 16.24% at P28, respectively, in <jats:italic>Bbx<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice. The second molar of <jats:italic>Bbx<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice also showed 10.16% and 6.4% reductions at P28 in the mesial and distal lengths, compared with <jats:italic>Bbx<\/jats:italic><jats:sup>+\/+<\/jats:sup> mice, respectively. The gene expression analysis during early tooth root formation (P13) showed that the expression of dentin sialophosphoprotein (<jats:italic>Dspp<\/jats:italic>) was significantly decreased in <jats:italic>Bbx<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice. Collectively, our data suggest that Bbx participates in tooth root formation and might be associated with the regulation of <jats:italic>Dspp<\/jats:italic> expression.<\/jats:p>","DOI":"10.1002\/jcp.29875","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T04:08:33Z","timestamp":1592194113000},"page":"480-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bobby sox homolog regulates tooth root formation through modulation of dentin sialophosphoprotein"],"prefix":"10.1002","volume":"236","author":[{"given":"Hye Jung","family":"Ihn","sequence":"first","affiliation":[{"name":"Institute for Hard Tissue and Biotooth Regeneration Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Ang","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Regenerative Medicine, School of Dentistry, Institute for Hard Tissue and Biotooth Regeneration Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Regenerative Medicine, School of Dentistry, Institute for Hard Tissue and Biotooth Regeneration Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Hyeon","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Regenerative Medicine, School of Dentistry, Institute for Hard Tissue and Biotooth Regeneration Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Hyeon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Regenerative Medicine, School of Dentistry, Institute for Hard Tissue and Biotooth Regeneration Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, School of Dentistry Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6752-5683","authenticated-orcid":false,"given":"Jae\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Dentistry Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, School of Medicine Kyungpook National University  Daegu Republic of 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