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Its basic characteristics are ovulatory dysfunction and ovarian overproduction of androgens that lead to severe symptoms such as insulin resistance, hirsutism, infertility, and acne. Notwithstanding the disease burden, its underlying mechanisms remain unknown, and no causal therapeutic exists. In recent years, further studies showed that inflammation processes are involved in ovulation and play a key role in ovarian follicular dynamics. Visceral adipose tissue can cause inflammatory response and maintenance of the inflammation state in adipocytes by augmented production of inflammatory cytokines, monocyte chemoattractant proteins, and recruitment of the immune cell. Therefore, the PCOS can be related to a low\u2010grade inflammation state and inflammatory markers. Investigating the inflammatory processes and mediators that contribute to the commencement and development of PCOS can be a critical step for better understanding the pathophysiology of the disease and its treatment through inhibition or control of related pathways. In the present review, we discuss the pathophysiological roles of chronic low\u2010grade inflammation mediators including\u00a0inflammasome\u2010related cytokines, interleukin\u20101\u03b2 (IL\u20101\u03b2), and IL\u201018 in PCOS development.<\/jats:p>","DOI":"10.1002\/jcp.29912","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T01:36:48Z","timestamp":1593740208000},"page":"824-838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":230,"title":["Pathophysiological roles of chronic low\u2010grade inflammation mediators in polycystic ovary syndrome"],"prefix":"10.1002","volume":"236","author":[{"given":"Maryam","family":"Rostamtabar","sequence":"first","affiliation":[{"name":"Student Research Committee, Babol University of Medical Sciences Babol 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