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However, the effect and mechanism of Sox4 in myocardial infarction (MI) remains\u00a0unclear. Therefore, we aimed\u00a0at\u00a0examining\u00a0the role and molecular mechanism of Sox4 in the process of cardiomyocytes apoptosis during MI. The expression of Sox4 were obviously increased both in MI mice and in neonatal mouse cardiomyocytes treated with H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. Overexpression of Sox4 promoted cardiomyocyte\u00a0apoptosis with or without H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, whereas knocking down of Sox4 alleviated H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010induced apoptosis in cardiomyocytes. Furthermore, silencing Sox4 by AAV\u20109 carried short hairpin RNA targeting Sox4 (AAV\u20109\u2010sh\u2010Sox4) markedly decreased cardiac infarct area, imprfoved cardiac dysfunction, and reversed apoptosis in MI mice. Mechanistically, there is a potential Sox4\u2010binding site in the promoter region of Bim, and forced expression of Sox4 significantly promoted Bim expression in cultured cardiomyocytes with or without H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, whereas knocking down of Sox4 inhibited the expression of Bim. Further studies showed that silencing Bim attenuated Sox4\u2010induced apoptosis in cardiomyocytes, indicating that Sox4 promoted cardiomyocytes apoptosis through regulation of Bim expression, which can be used as a potential therapeutic target for MI.<\/jats:p>","DOI":"10.1002\/jcp.29918","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T10:20:34Z","timestamp":1594635634000},"page":"1094-1104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Suppression of Sox4 protects against myocardial ischemic injury by reduction of cardiac apoptosis in mice"],"prefix":"10.1002","volume":"236","author":[{"given":"Lijia","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacology (State\u2010Province Key Laboratories of Biomedicine\u2010Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Pharmacology (State\u2010Province Key Laboratories of Biomedicine\u2010Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy Harbin Medical University  Harbin Heilongjiang China"},{"name":"Department of Basic Medicine, The Centre of Functional Experiment Teaching Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology (State\u2010Province Key Laboratories of Biomedicine\u2010Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy Harbin Medical University  Harbin Heilongjiang 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