{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:05:23Z","timestamp":1784354723851,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2018YFC2001902"],"award-info":[{"award-number":["2018YFC2001902"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myocardial infarction is a major cause of death worldwide. Despite our understanding of the pathophysiology of myocardial infarction and the therapeutic options for treatment have improved substantially, acute myocardial infarction remains a leading cause of morbidity and mortality. Recent findings revealed that GRP78 could protect myocardial cells against ischemia reperfusion injury\u2010induced apoptosis, but the exact function and molecular mechanism remains unclear. In this study, we aimed to explore the effects of GRP78 on hypoxia\/reperfusion (H\/R)\u2010induced cardiomyocyte injury. Intriguingly, we first observed that GRP78 overexpression significantly protected myocytes from H\/R\u2010induced apoptosis. On mechanism, our work revealed that GRP78 protected myocardial cells from hypoxia\/reperfusion\u2010induced apoptosis via the activation of the Nrf2\/HO\u20101 signaling pathway. We observed the enhanced expression of Nrf2\/HO\u20101 in GRP78 overexpressed H9c2 cell, while GRP78 deficiency dramatically antagonized the expression of Nrf2\/HO\u20101. Furthermore, we found that blocked the Nrf2\/HO\u20101 signaling by the HO\u20101 inhibitor zinc protoporphyrin IX (Znpp) significantly retrieved H9c2 cells apoptosis that inhibited by GRP78 overexpression. Taken together, our findings revealed a new mechanism by which GRP78 alleviated H\/R\u2010induced cardiomyocyte apoptosis in H9c2 cells via the promotion of the Nrf2\/HO\u20101 signaling pathway.<\/jats:p>","DOI":"10.1002\/jcp.29929","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T10:05:35Z","timestamp":1594634735000},"page":"1228-1236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["GRP78 effectively protect hypoxia\/reperfusion\u2010induced myocardial apoptosis via promotion of the Nrf2\/HO\u20101 signaling pathway"],"prefix":"10.1002","volume":"236","author":[{"given":"Heyu","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The Second Xiangya Hospital Central South University  Changsha Hunan 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Central South University  Changsha Hunan China"},{"name":"Department of Anesthesiology Affiliated Hospital of Binzhou Medical University  Binzhou Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junmei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Xiangya Hospital Central South University  Changsha Hunan 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