{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:48:15Z","timestamp":1790804895384,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["ECR\/2016\/001688"],"award-info":[{"award-number":["ECR\/2016\/001688"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The emergence of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), the agent of novel coronavirus 2019 (COVID\u201019), has kept the globe in disquiets due to its severe life\u2010threatening conditions. The most common symptoms of COVID\u201019 are fever, sore throat, and shortness of breath. According to the anecdotal reports from the health care workers, it has been suggested that the virus could reach the brain and can cause anosmia, hyposmia, hypogeusia, and hypopsia. Once the SARS\u2010CoV\u20102 has entered the central nervous system (CNS), it can either exit in an inactive form in the tissues or may lead to neuroinflammation. Here, we aim to discuss the chronic infection of the olfactory bulb region of the brain by SARS\u2010CoV\u20102 and how this could affect the nearby residing neurons in the host. We further review the probable cellular mechanism and activation of the microglia 1 phenotype possibly leading to various neurodegenerative disorders. In conclusion, SARS\u2010CoV\u20102 might probably infect the olfactory bulb neuron enervating the nasal epithelium accessing the CNS and might cause neurodegenerative diseases in the future.<\/jats:p>","DOI":"10.1002\/jcp.29937","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T14:10:10Z","timestamp":1595427010000},"page":"763-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["COVID\u201019 and olfactory dysfunction: A possible associative approach towards neurodegenerative diseases"],"prefix":"10.1002","volume":"236","author":[{"given":"Iyer","family":"Mahalaxmi","sequence":"first","affiliation":[{"name":"Department of Zoology Avinashilingam Institute for Home Science and Higher Education  Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8378-6197","authenticated-orcid":false,"given":"Jayaramayya","family":"Kaavya","sequence":"additional","affiliation":[{"name":"Department of Zoology Avinashilingam Institute for Home Science and Higher Education  Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramaniam","family":"Mohana Devi","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Biology Vision Research Foundation  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3043-6839","authenticated-orcid":false,"given":"Vellingiri","family":"Balachandar","sequence":"additional","affiliation":[{"name":"Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology Bharathiar University  Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2020.05.017"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-323522"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyaa204"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.116832"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00122"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.139021"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8562805"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000781"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00201"},{"issue":"20","key":"e_1_2_6_11_1","first-page":"30676","article-title":"SARS\u2010CoV\u20102: A new virus but a familiar inflammation brain pattern","volume":"0889","author":"De Santis G.","year":"2020","journal-title":"Brain, Behavior, and Immunity"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1560"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009700"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2012.0088"},{"issue":"3","key":"e_1_2_6_15_1","first-page":"e7352","article-title":"Neurological complications of coronavirus disease (COVID\u201019): Encephalopathy","volume":"12","author":"Filatov A.","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.00243"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26865"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2020.53.4.080"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.02.001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25807"},{"key":"e_1_2_6_21_1","first-page":"1","article-title":"Olfactory and gustatory dysfunctions as a clinical presentation of mild\u2010to\u2010moderate forms of the coronavirus disease (COVID\u201019): A multicenter European study","author":"Lechien J. 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