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Recent studies found that ephrinB2\u2010EPHB4 forward signaling mediated the anabolic effect of PTH in bone homeostasis. Considering the similarities between cementum and bone, we aimed to examine the therapeutic effect of PTH on resorbed roots and explore the role of forward signaling in this process. In vivo experiments showed that intermittent PTH significantly accelerated the regeneration of root resorption and promoted expression of EPHB4 and ephrinB2. When the signaling was blocked, the resorption repair was also delayed. In vitro studies showed that intermittent PTH promoted the expression of EPHB4 and ephrinB2 in OCCM\u201030 cells. The effects of PTH on the mineralization capacity of OCCM\u201030 cells was mediated through the ephrinB2\u2010EPHB4 forward signaling. These results support the premise that the anabolic effects of intermittent PTH on the regeneration of root resorption is via the ephrinB2\u2010EPHB4 forward signaling pathway.<\/jats:p>","DOI":"10.1002\/jcp.29994","type":"journal-article","created":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T05:27:42Z","timestamp":1596346062000},"page":"2070-2086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Intermittent parathyroid hormone promotes cementogenesis via ephrinB2\u2010EPHB4 forward signaling"],"prefix":"10.1002","volume":"236","author":[{"given":"Tiancheng","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases Sichuan University  Chengdu China"},{"name":"Department of Orthodontics, West China School and Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases Sichuan University  Chengdu China"},{"name":"Department of Orthodontics, West China School and Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiao","family":"Lv","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases Sichuan University  Chengdu China"},{"name":"Department of Orthodontics, West China School and Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases Sichuan University  Chengdu China"},{"name":"Department of Orthodontics, West China School and Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases Sichuan University  Chengdu China"},{"name":"Department of Orthodontics, West China School and Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases Sichuan University  Chengdu China"},{"name":"Department of Pediatric Dentistry, West China School and Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Zou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases Sichuan University  Chengdu China"},{"name":"Department of Orthodontics, West China School and Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4111-8112","authenticated-orcid":false,"given":"Peipei","family":"Duan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases Sichuan University  Chengdu China"},{"name":"Department of Orthodontics, West China School and Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2007.04.035"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080324"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"235","article-title":"Effects of cell\u2010mediated osteoprotegerin gene transfer and mesenchymal stem cell applications on orthodontically induced root resorption of rat teeth","volume":"39","author":"Amuk N. 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