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It acts synergistically with IL\u201012 in the Th1 paradigm, whereas with IL\u20102 and without IL\u201012 it can induce Th2 cytokine production from cluster of differentation (CD)4<jats:sup>+<\/jats:sup> T cells, natural killer (NK cells, NKT cells, as well as from Th1 cells. IL\u201018 also plays a role in the hemophagocytic lymphohistiocytosis, a life\u2010threatening condition characterized by a cytokine storm that can be secondary to infections. IL\u201018\u2010mediated inflammation was largely studied in animal models of bacterial, viral, parasitic, and fungal infections. These studies highlight the contribution of either IL\u201018 overproduction by the host or overresponsiveness of the host to IL\u201018 causing an exaggerated inflammatory burden and leading to tissue injury. Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) is responsible for the coronavirus disease 2019 (COVID\u201019). The damage in the later phase of the disease appears to be driven by a cytokine storm, including interleukin IL\u20101 family members and secondary cytokines like IL\u20106. IL\u201018 may participate in this hyperinflammation, as it was previously found to be able to cause injury in the lung tissue of infected animals. IL\u201018 blockade has become an appealing therapeutic target and has been tested in some IL\u201018\u2010mediated rheumatic diseases and infantile\u2010onset macrophage activation syndrome. Given its role in regulating the immune response to infections, IL\u201018 blockade might represent a therapeutic option for COVID\u201019, although further studies are warranted to investigate more in detail the exact role of IL\u201018 in SARS\u2010CoV\u20102 infection.<\/jats:p>","DOI":"10.1002\/jcp.30008","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T14:23:57Z","timestamp":1597415037000},"page":"1638-1657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["IL\u201018 and infections: Is there a role for targeted therapies?"],"prefix":"10.1002","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0410-5996","authenticated-orcid":false,"given":"Alessandra","family":"Vecchi\u00e9","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Pauley Heart Center Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4747-5535","authenticated-orcid":false,"given":"Aldo","family":"Bonaventura","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Pauley Heart Center Virginia Commonwealth University  Richmond Virginia"},{"name":"Department of Internal Medicine, First Clinic of Internal Medicine University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1588-4019","authenticated-orcid":false,"given":"Stefano","family":"Toldo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Pauley Heart Center Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7428-315X","authenticated-orcid":false,"given":"Lorenzo","family":"Dagna","sequence":"additional","affiliation":[{"name":"Unit of Immunology, Rheumatology, Allergy and Rare Diseases IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Dinarello","sequence":"additional","affiliation":[{"name":"Department of Medicine and Immunology University of Colorado School of Medicine  Aurora Colorado"},{"name":"Department of Medicine Radboud University Medical Center  Nijmegen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1930-785X","authenticated-orcid":false,"given":"Antonio","family":"Abbate","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Pauley Heart Center Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.315937"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0371-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx050"},{"issue":"2","key":"e_1_2_10_5_1","first-page":"197","article-title":"Hemophagocytic lymphohistiocytosis. 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