{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:52:28Z","timestamp":1791287548975,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>N<jats:sup>6<\/jats:sup>\u2010methyladenosine (m<jats:sup>6<\/jats:sup>A) and long noncoding RNAs (lncRNAs) are both crucial regulators in non\u2010small\u2010cell lung cancer (NSCLC) tumorigenesis. However, the pathological roles of m<jats:sup>6<\/jats:sup>A and lncRNAs in NSCLC progression are still limited and undefined. Here, lncRNA ABHD11\u2010AS1 was upregulated in NSCLC tissue specimens and cells and the ectopic overexpression was closely correlated with unfavorable prognosis of NSCLC patients. Functionally, ABHD11\u2010AS1 promoted the proliferation and Warburg effect of NSCLC. Mechanistically, m<jats:sup>6<\/jats:sup>A profile was analyzed by methylated RNA immunoprecipitation sequencing (MeRIP\u2010Seq). MeRIP\u2010Seq presented that there was m<jats:sup>6<\/jats:sup>A modification site in ABHD11\u2010AS1. m<jats:sup>6<\/jats:sup>A methyltransferase\u2010like 3 (METTL3) installed the m<jats:sup>6<\/jats:sup>A modification and enhanced ABHD11\u2010AS1 transcript stability to increase its expression. In conclusion, our findings highlight the function and mechanism of METTL3\u2010induced ABHD11\u2010AS1 in NSCLC and inspire the understanding of m<jats:sup>6<\/jats:sup>A and lncRNA in cancer biology.<\/jats:p>","DOI":"10.1002\/jcp.30023","type":"journal-article","created":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T08:14:32Z","timestamp":1599380072000},"page":"2649-2658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":140,"title":["m<sup>6<\/sup>A transferase METTL3\u2010induced lncRNA ABHD11\u2010AS1 promotes the Warburg effect of non\u2010small\u2010cell lung cancer"],"prefix":"10.1002","volume":"236","author":[{"given":"Lei","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery The Third Affiliated Hospital of Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Third Affiliated Hospital of Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Degang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Third Affiliated Hospital of Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Third Affiliated Hospital of Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinting","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Third Affiliated Hospital of Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8860-1086","authenticated-orcid":false,"given":"Jiangzhou","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Third Affiliated Hospital of Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.12.009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.1390"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11232-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.24896"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2018-135862"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2016.883"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2020.104411"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.12.015"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.12.003"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.02.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0830-6"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01161-1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.07.068"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-2965"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.10.002"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-019-0170-y"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102950"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015793"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16524"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1036-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01194-6"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102911"},{"key":"e_1_2_6_24_1","first-page":"317","article-title":"Tests on surviving carcinoma cultures","volume":"142","author":"Warburg O.","year":"1923","journal-title":"Biochem, Z"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01512"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0755-0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.02.002"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.09.028"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0052-1"},{"issue":"12","key":"e_1_2_6_30_1","first-page":"2377","article-title":"Detection and application of circulating tumor cell and circulating tumor DNA in the non\u2010small cell lung cancer","volume":"8","author":"Zhang Y.","year":"2018","journal-title":"American Journal of Cancer Research"},{"issue":"1","key":"e_1_2_6_31_1","first-page":"35","article-title":"m(6)A\u2010binding proteins: The emerging crucial performers in epigenetics","volume":"13","author":"Zhao Y.","year":"2020","journal-title":"Cancer Biology & Medicine"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.30023","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.30023","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.30023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T11:20:42Z","timestamp":1732792842000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.30023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,6]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/jcp.30023"],"URL":"https:\/\/doi.org\/10.1002\/jcp.30023","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,6]]},"assertion":[{"value":"2020-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}