{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:58:08Z","timestamp":1790827088730,"version":"4.1.0"},"reference-count":94,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T00:00:00Z","timestamp":1608422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neutrophils with their array of microbicidal activities are the first innate immune cells to guard against infection. They are also most crucial for the host's initial defense against <jats:italic>Leishmania<\/jats:italic> parasites which cause clinically diverse diseases ranging from self\u2010healing cutaneous leishmaniasis (CL) to a more severe visceral form, visceral leishmaniasis (VL). Neutrophils are recruited in large numbers at the infection site after bite of sandfly, which is the vector for the disease. The initial interaction of neutrophils with the parasites may modulate the subsequent innate and adaptive immune responses and hence affect the disease outcome. The purpose of this review is to comprehensively appraise the role of neutrophils during the early stages of <jats:italic>Leishmania<\/jats:italic> infection with a focus on the visceral form of the disease. In the past decade, new insights regarding the role of neutrophils in VL have surfaced which have been extensively elaborated in the present review. In addition, since much of the information regarding neutrophil\u2013<jats:italic>Leishmania<\/jats:italic> early interaction has accumulated through studies on mouse models of CL, these studies are also revisited. We begin by reviewing the factors which drive the recruitment of neutrophils at the site of injection by the sandfly. We then discuss the studies delineating the molecular mechanisms involved in the uptake of the <jats:italic>Leishmania<\/jats:italic> parasite by neutrophils and how the parasite subverts their microbicidal functions. In the end, the interaction of infected neutrophils with macrophages and dendritic cells is summarized.<\/jats:p>","DOI":"10.1002\/jcp.30029","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T17:10:03Z","timestamp":1608570603000},"page":"2255-2267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Neutrophils and Visceral Leishmaniasis: Impact on innate immune response and cross\u2010talks with macrophages and dendritic cells"],"prefix":"10.1002","volume":"236","author":[{"given":"Manu","family":"Kupani","sequence":"first","affiliation":[{"name":"Department of Human Genetics Guru Nanak Dev University Amritsar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev K.","family":"Pandey","sequence":"additional","affiliation":[{"name":"Research &amp; Development Thermo Fisher Scientific Bengaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1186-5718","authenticated-orcid":false,"given":"Sanjana","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Guru Nanak Dev University Amritsar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2014.07.028"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0108018"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.2.898"},{"issue":"1","key":"e_1_2_11_5_1","first-page":"137","article-title":"Immunopathology of experimental cutaneous leishmaniasis","volume":"114","author":"Andrade Z. 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