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Forced emergence to find an effective vaccine to immunize people has led scientists to design and examine vaccine candidates all over the world. Until a vaccine is developed, however, effective treatment is needed to combat this virus, which is resistant to all conventional antiviral drugs. Accordingly, more about the structure, entry mechanism, and pathogenesis of COVID\u201019 is required. Angiotensin\u2010converting enzyme 2 (ACE2) is the gateway to SARS\u2010CoV and SARS\u2010CoV\u20102, so our knowledge of SARS\u2010CoV\u20102 can help us to complete its mechanism of interaction with ACE2 and virus endocytosis, which can be interrupted by neutralizing small molecules or proteins. 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