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SNAREs mediate core membrane fusion processes essential for all cells, but some SNAREs serve cell\/tissue type\u2010specific exocytic\/endocytic functions, and are therefore critical for various aspects of embryonic development. Mutations or variants of their encoding genes could give rise to developmental disorders, such as those affecting the nervous system and immune system in humans. Mutations to components in the canonical synaptic vesicle fusion SNARE complex (VAMP2, STX1A\/B, and SNAP25) and a key regulator of SNARE complex formation MUNC18\u20101, produce variant phenotypes of autism, intellectual disability, movement disorders, and epilepsy. <jats:italic>STX11<\/jats:italic> and <jats:italic>MUNC18\u20102<\/jats:italic> mutations underlie 2 subtypes of familial hemophagocytic lymphohistiocytosis. <jats:italic>STX3<\/jats:italic> mutations contribute to variant microvillus inclusion disease. Chromosomal microdeletions involving <jats:italic>STX16<\/jats:italic> play a role in pseudohypoparathyroidism type IB associated with abnormal imprinting of the <jats:italic>GNAS<\/jats:italic> complex locus. In this short review, I discuss these and other SNARE gene mutations and variants that are known to be associated with a variety developmental disorders, with a focus on their underlying cellular and molecular pathological basis deciphered through disease modeling. Possible pathogenic potentials of other SNAREs whose variants could be disease predisposing are also speculated upon.<\/jats:p>","DOI":"10.1002\/jcp.30067","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T11:22:10Z","timestamp":1600773730000},"page":"2482-2504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["SNAREs and developmental disorders"],"prefix":"10.1002","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1925-636X","authenticated-orcid":false,"given":"Bor L.","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Yong Loo Lin School of Medicine National University of Singapore  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