{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T09:04:48Z","timestamp":1782810288461,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660104"],"award-info":[{"award-number":["81660104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760114"],"award-info":[{"award-number":["81760114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860673"],"award-info":[{"award-number":["81860673"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960779"],"award-info":[{"award-number":["81960779"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62061012"],"award-info":[{"award-number":["62061012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to investigate the role of scoparone (SCO) in hepatic fibrosis. For this, we conducted in vivo and in vitro experiments. In vivo rats that were divided into six groups, control, carbon tetrachloride, and colchicine, as well as SCO groups, SCO50, SCO100, and SCO200 treated with 50, 100, and 200\u2009mg\/kg SCO doses, respectively. Furthermore, SCO was shown to inhibit Toll\u2010like receptor\u20104 (TLR\u20104)\/nuclear factor kappa\u2010B (NF\u2010\u03baB; TLR\u20104\/NF\u2010\u03baB) signals by inhibiting TLR\u20104, which in turn downregulates the expression of MyD88, promotes NF\u2010\u03baB inhibitor\u2010\u03b1, NF\u2010\u03baB inhibitor\u2010\u03b2, and NF\u2010\u03baB inhibitor\u2010\u03b5 activation, while inhibiting NF\u2010\u03baB inhibitor\u2010\u03b6. Subsequently, the decrease of phosphorylation of nuclear factor\u2010\u03baB levels leads to the downregulation of the downstream inflammatory factors' tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), interleukin\u20106 (IL\u20106), and IL\u20101 beta, thus weakening hepatic fibrosis. Notably, the SCO200 treated group presented the most significant improvement. Hence, we conclude that SCO alleviates hepatic fibrosis by inhibiting TLR\u20104\/NF\u2010\u03baB signals.<\/jats:p>","DOI":"10.1002\/jcp.30083","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T05:50:03Z","timestamp":1602222603000},"page":"3044-3058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Scoparone alleviates hepatic fibrosis by inhibiting the TLR\u20104\/NF\u2010\u03baB pathway"],"prefix":"10.1002","volume":"236","author":[{"given":"Ya","family":"Gao","sequence":"first","affiliation":[{"name":"College of Pharmacy Guilin Medical University Guilin Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boting","family":"Xi","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guilin Medical University Guilin Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guilin Medical University Guilin Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimeng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guilin Medical University Guilin Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guilin Medical University Guilin Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingli","family":"Zhong","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guilin Medical University Guilin Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongmei","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guilin Medical University Guilin Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyu","family":"Lian","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guilin Medical University Guilin Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riming","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guilin Medical University Guilin Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6372-5939","authenticated-orcid":false,"given":"Liping","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guilin Medical University Guilin Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houkang","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Pharmacy Gansu University of Chinese Medicine Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Pharmacy Gansu University of Chinese Medicine Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guilin Medical University Guilin Guangxi China"},{"name":"College of Pharmacy Gansu University of Chinese Medicine Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9754-7683","authenticated-orcid":false,"given":"Jianghui","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guilin Medical University Guilin Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2015-0284"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-016-1210-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.06.025"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2018.03.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7053119"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8111419"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.11.055"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.60"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.11.028"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.11.047"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29528"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2016-0157"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP278478"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.11.006"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO00700K"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25955"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.06.047"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.01.028"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43834"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29520"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7808656"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S224618"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105797"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2016.01.012"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18038"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat5024"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.06.006"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.07.062"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1534"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29556"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13677"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.226936"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.08.014"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50182"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01138"},{"issue":"7","key":"e_1_2_9_37_1","first-page":"535","article-title":"Study on the effects of total flavonoids from litchi nucleus on nuclear translocation of nuclear factor\u2010kappa B and related protein expression in rat hepatic stellate cell","volume":"26","author":"Qin G. J.","year":"2018","journal-title":"Chinese journal of hepatology"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2014.07.008"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x20175692"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1663"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12877"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02297"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.022"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23463"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190617"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45006"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31012-1"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000373974"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b04128"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.09.127"},{"key":"e_1_2_9_51_1","doi-asserted-by":"crossref","unstructured":"Yoon Y. J. Friedman S. L. &Lee Y. A.(2016).Antifibrotic therapies: where are we now?Paper presented at the Seminars in liver disease.","DOI":"10.1055\/s-0036-1571295"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep06768"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.12.053"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.11.088"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.111860"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2019.153"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.30083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.30083","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.30083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T11:18:10Z","timestamp":1732792690000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.30083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,8]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/jcp.30083"],"URL":"https:\/\/doi.org\/10.1002\/jcp.30083","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,8]]},"assertion":[{"value":"2020-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}