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CircRNA expression profiles in OA and normal cartilage tissues were detected by microarray. The expression pattern, functional role, and mechanisms of CircCDH13 in OA were studied in vitro and in vivo. Gain\u2010of\u2010function and loss\u2010of\u2010function approaches were used to demonstrate the participation of CircCDH13 in OA. The regulatory relationship between CircCDH13 and miR\u2010296\u20103p and\u00a0miR\u2010296\u20103p\u00a0and phosphatase and tensin homolog (PTEN) was predicted by bioinformatics\u00a0and verified by RNA pulldown and luciferase assay. Adeno\u2010associated virus was also used to reveal the role and mechanisms of CircCDH13 in destabilization of medial meniscus (DMM)\u2010induced OA mice. The upregulation of CircCDH13 in OA cartilage tissues significantly induces chondrocyte apoptosis, promotes extracellular matrix (ECM) catabolism, and inhibits ECM anabolism. Mechanistically, CircCDH13 contributes to OA pathogenesis by functioning as a sponge of miR\u2010296\u20103p and regulating the miR\u2010296\u20103p\u2010PTEN pathway. Silencing of CircCDH13 in vivo markedly alleviated DMM\u2010induced OA in mice. Our study revealed an important role of CircCDH13 in OA pathogenesis. Silencing of CircCDH13 could reduce chondrocyte apoptosis, inhibit ECM catabolism, and promote ECM anabolism through the miR\u2010296\u20103p\u2010PTEN pathway. It provides a potential target for developing effective interventions in treating OA.<\/jats:p>","DOI":"10.1002\/jcp.30091","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T07:09:46Z","timestamp":1602313786000},"page":"3521-3535","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Circular RNA CircCDH13 contributes to the pathogenesis of osteoarthritis via CircCDH13\/miR\u2010296\u20103p\/PTEN axis"],"prefix":"10.1002","volume":"236","author":[{"given":"Zhibin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Orthopaedics General Hospital of Northern Theater Command  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Changzheng Hospital Navy Medical University  Shanghai 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