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Although many signaling pathways have been reported to be involved in the hypertrophic process, it is still not fully clear about the underlying molecular mechanisms for cardiac hypertrophy. Hedgehog acyltransferase\u2010like (Hhatl), a sarcoplasmic reticulum\u2010resident protein, exhibits high expression in the heart and muscle. However, the biological role of Hhatl in the heart remains unknown. In this study, we first found that the expression level of Hhatl is markedly decreased in cardiac hypertrophy. We further studied the role of <jats:italic>hhatla<\/jats:italic>, homolog of <jats:italic>Hhatl<\/jats:italic> with the zebrafish model. The depletion of <jats:italic>hhatla<\/jats:italic> in zebrafish leads to cardiac defects, as well as an enhanced level of hypertrophic markers. Besides, we found that calcineurin signaling participates in <jats:italic>hhatla<\/jats:italic> depletion\u2010induced cardiac hypertrophy. Together, these results demonstrate a critical role for <jats:italic>hhatla<\/jats:italic> in cardiac hypertrophy.<\/jats:p>","DOI":"10.1002\/jcp.30106","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T19:25:55Z","timestamp":1602703555000},"page":"3700-3709","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Zebrafish <i>hhatla<\/i> is involved in cardiac hypertrophy"],"prefix":"10.1002","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6955-9836","authenticated-orcid":false,"given":"Xingjuan","family":"Shi","sequence":"first","affiliation":[{"name":"School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease Southeast University  Nanjing 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