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This study investigated the roles of the \u03b2\u2010catenin signaling pathway in bone and bone marrow recovery potentials in rats treated with antimetabolite methotrexate (MTX) (five once\u2010daily injections, 0.75\u2009mg\/kg) with\/without \u03b2\u2010catenin inhibitor indocyanine green (ICG)\u2010001 (oral, 200\u2009mg\/kg\/day). ICG alone reduced trabecular bone volume and bone marrow cellularity. In MTX\u2010treated rats, ICG suppressed bone volume recovery on Day 11 after the first MTX injection. ICG exacerbated MTX\u2010induced decreases on Day 9 osteoblast numbers on bone surfaces, their formation in vitro from bone marrow stromal cells (osteogenic differentiation\/mineralization), as well as expression of osteogenesis\u2010related markers Runx2, Osx, and OCN in bone, and it suppressed their subsequent recoveries on Day 11. On the other hand, ICG did not affect MTX\u2010induced increased osteoclast density and the level of the osteoclastogenic signal (RANKL\/OPG expression ratio) in bone, suggesting that ICG inhibition of \u03b2\u2010catenin does nothing to abate the increased bone resorption induced by MTX. ICG also attenuated bone marrow cellularity recovery on Day 11, which was associated with the suppressed recovery of CD34<jats:sup>+<\/jats:sup> or c\u2010Kit<jats:sup>+\u00a0<\/jats:sup>hematopoietic progenitor cell contents. Thus, \u03b2\u2010catenin signaling is important for osteogenesis and hematopoiesis recoveries following MTX chemotherapy.<\/jats:p>","DOI":"10.1002\/jcp.30114","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T07:50:26Z","timestamp":1603180226000},"page":"3740-3751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["\u03b2\u2010Catenin signaling is important for osteogenesis and hematopoiesis recovery following methotrexate chemotherapy in rats"],"prefix":"10.1002","volume":"236","author":[{"given":"Jian","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Tongji Hospital Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Wen","family":"Su","sequence":"additional","affiliation":[{"name":"UniSA Clinical and Health Sciences University of South Australia Adelaide South Australia 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