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However, recent data suggest that MYC also controls the establishment of the tumour microenvironment and that \u201concogene addiction\u201d actually has a strong immune background. Evaluation of the MYC role in the immunoediting process led to the speculation that cancer just uses and distorts the physiological mechanism by which MYC normally prevents rapidly proliferating cells from the elicitation of an autoimmune response. Concordantly, elevated levels of MYC and induction of immunosuppressive molecules are observed during the processes of growth and development, tissue repair, placenta development, and so forth, implying that MYC may be involved in saving regular physiologically proliferating cells from the immune system attack. Even more, a growing body of evidence suggests MYC involvement in the shaping of the adaptive immune response, immunological memory development, and establishment of immunotolerance. This paper offers an overview of MYC actions in the context of modulation of the immune response in pathological and physiological conditions. The determination of such a new role for a well\u2010known oncogene opens new perspectives in biomedicine, and consequently, in the treatment of various pathological conditions.<\/jats:p>","DOI":"10.1002\/jcp.30123","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T14:33:11Z","timestamp":1603463591000},"page":"3234-3243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The new role for an old guy: MYC as an immunoplayer"],"prefix":"10.1002","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6730-4370","authenticated-orcid":false,"given":"Dragan","family":"Marinkovic","sequence":"first","affiliation":[{"name":"Faculty of Special Education and Rehabilitation University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3956-1679","authenticated-orcid":false,"given":"Tatjana","family":"Marinkovic","sequence":"additional","affiliation":[{"name":"Western Serbia Academy of Applied Sciences Uzice Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1024602"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.01.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-11-742577"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac9935"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.10190"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21349"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a014357"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0915174107"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.19.1.1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.003"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","unstructured":"Dang\u2019 And C. 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