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The important findings can be summarized as follows: (i) adipogenesis and early stage \u03b2\u2010cell differentiation were\u00a0stimulated in duct cells under lipotoxicity and glucolipotoxicity conditions, (ii) <jats:italic>miR\u2010375<\/jats:italic> expression was upregulated while its target <jats:italic>Erk1<\/jats:italic> was downregulated\u00a0and miR\u2010375 inhibitor upregulated <jats:italic>Erk1<\/jats:italic> while expression of adipogenesis markers was downregulated\u00a0in duct cells under both conditions, (iii) apoptosis was induced in \u03b2\u00a0and duct cells under both conditions, (iv) lipotoxicity induced proliferation of co\u2010cultured \u03b2\u2010cells. These findings suggest that long\u2010term saturated fatty acid overexposure may cause intrapancreatic fat accumulation by inducing differentiation of duct cells into adipocytes and it may contributes to \u03b2\u2010cell compensation by stimulating the early stage of \u03b2\u2010cell differentiation in duct cells. In addition, miR\u2010375 may have the potential to be a new target in the treatment of Type 2 diabetes, and NAFPD due to its role in the adipogenesis of duct cells.<\/jats:p>","DOI":"10.1002\/jcp.30129","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T05:47:13Z","timestamp":1603777633000},"page":"3881-3895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["miR\u2010375 induces adipogenesis through targeting Erk1 in pancreatic duct cells under the influence of sodium palmitate"],"prefix":"10.1002","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1378-1585","authenticated-orcid":false,"given":"Selda","family":"Gezginci\u2010Oktayoglu","sequence":"first","affiliation":[{"name":"Biology Department, Molecular Biology Section, Faculty of Science Istanbul University Vezneciler Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7093-4744","authenticated-orcid":false,"given":"Serap","family":"Sancar","sequence":"additional","affiliation":[{"name":"Biology Department, Molecular Biology Section, Faculty of Science Istanbul University Vezneciler Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6032-470X","authenticated-orcid":false,"given":"Ayse","family":"Karatug\u2010Kacar","sequence":"additional","affiliation":[{"name":"Biology Department, Molecular Biology Section, Faculty of Science Istanbul University Vezneciler Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1112-5162","authenticated-orcid":false,"given":"Sehnaz","family":"Bolkent","sequence":"additional","affiliation":[{"name":"Biology Department, Molecular Biology Section, Faculty of Science Istanbul University Vezneciler Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12723"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02871"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-17-0516"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-543X.2004.00075.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2004.10.018"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.2.402"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339906775473644"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1306335"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.3.634"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2017.06.019"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2860"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.25286"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.99576"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88894"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.02.043"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.07.015"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4385-1"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.05.001"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26242"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1998.78.3.783"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2955"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.11.2481"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4627-x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20851"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805803105"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.173.5.10541101"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00847"},{"key":"e_1_2_10_29_1","first-page":"212","article-title":"Characteristics of two rat pancreatic exocrine cell lines derived from transplantable tumors","volume":"16","author":"Jessop N. 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