{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:03:06Z","timestamp":1789473786511,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872437"],"award-info":[{"award-number":["31872437"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Organic selenium has antioxidation and disease treatment effects. To explore the mechanisms of how methionine selenium alleviates necroptosis in the liver and whether this process is related to microRNA\u00a0(miRNA) and the mitogen\u2010activated protein kinase (MAPK) pathway,\u00a0an animal model of methionine selenium and the lipopolysaccharide (LPS) interaction was established. The morphology, inflammatory factor (tumor necrosis factor\u2010\u03b1 [TNF\u2010\u03b1]), necroptosis\u2010related genes (RIP1, RIP3, MLKL, and caspase 8), MAPK pathway\u2010related genes (JNK, ERK, and p38, p\u2010JNK, p\u2010ERK, and p\u2010p38), gga\u2010miR\u2010155, TRAF3 (predicted target of gga\u2010miR\u2010155), and oxidative stress\u2010related indicators (SOD, MDA, CAT, GSH, and GSH\u2010Px) were analyzed from the perspective of the miR\u2010155\/TRAF3\/MAPK axis to elucidate the mechanism of methionine selenium on the LPS\u2010induced necroptosis mechanism in the chicken liver. The current results suggested that methionine selenium antagonizes oxidative stress, inflammation, and the MAPK pathway, thereby antagonizing the occurrence of necroptosis through multiple mechanisms. At the same time, methionine selenium affects miR\u2010155\/TRAF3\/MAPK signaling, reduces miR\u2010155 expression, and upregulates TRAF3 expression to inhibit necroptosis. This\u00a0information provided new ideas and a theoretical basis for the practical application of methionine selenium, and it also enriched the study of miRNAs in birds and provided a reference for comparative medicine.<\/jats:p>","DOI":"10.1002\/jcp.30145","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T15:01:54Z","timestamp":1604588514000},"page":"4024-4035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Methionine selenium antagonizes LPS\u2010induced necroptosis in the chicken liver via the miR\u2010155\/TRAF3\/MAPK axis"],"prefix":"10.1002","volume":"236","author":[{"given":"Zhao","family":"Zhirong","sequence":"first","affiliation":[{"name":"Department of Basic Veterinary Medicine, College of Veterinary Medicine Northeast Agricultural University  Harbin People's Republic of 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