{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:17Z","timestamp":1786978037812,"version":"build-2736575974"},"reference-count":76,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["AG064674\u201001A1"],"award-info":[{"award-number":["AG064674\u201001A1"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clinical reports suggest a high incidence of ICU mortality with the use of hyperoxia during mechanical ventilation in patients. Our laboratory is pioneer in studying effect of hyperoxia on cardiac pathophysiology. In this study for the first time, we are reporting the sequence of cardiac pathophysiological events in mice under hyperoxic conditions in time\u2010dependent manner. C57BL\/6J male mice, aged 8\u201310 weeks, were treated with either normal air or &gt;90% oxygen for 24, 48, and 72\u2009h. Following normal air or hyperoxia treatment, physical, biochemical, functional, electrical, and molecular parameters were analyzed. Our data showed that significant reduction of body weight observed as early as 24\u2009h hyperoxia treatment, whereas, no significant changes in heart weight until 72\u2009h. Although we do not see any fibrosis in these hearts, but observed significant increase in cardiomyocyte size with hyperoxia treatment in time\u2010dependent manner. Our data also demonstrated that arrhythmias were present in mice at 24\u2009h hyperoxia, and worsened comparatively after 48 and 72\u2009h. Echocardiogram data confirmed cardiac dysfunction in time\u2010dependent manner. Dysregulation of ion channels such as Kv4.2 and KChIP2; and serum cardiac markers confirmed that hyperoxia\u2010induced effects worsen with each time point. From these observations, it is evident that electrical remodeling precedes structural remodeling, both of which gets worse with length of hyperoxia exposure, therefore shorter periods of hyperoxia exposure is always beneficial for better outcome in ICU\/critical care units.<\/jats:p>","DOI":"10.1002\/jcp.30165","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:48:32Z","timestamp":1606178912000},"page":"4482-4495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Electrical remodeling and cardiotoxicity precedes structural and functional remodeling of mouse hearts under hyperoxia treatment"],"prefix":"10.1002","volume":"236","author":[{"given":"Jennifer L.","family":"Rodgers","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy University of South Florida Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahit","family":"Vanthenapalli","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy University of South Florida Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siva K.","family":"Panguluri","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy University of South Florida Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000592"},{"issue":"1","key":"e_1_2_9_3_1","first-page":"38","article-title":"Study of cardiac autonomic neuropathy and its association with QTc dispersion in patients with type\u20102 diabetes mellitus","volume":"64","author":"Anasuya M.","year":"2016","journal-title":"Journal of the Association of Physicians of India"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199012000-00015"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.2.955"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.19.4.3173"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.01.007"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13078"},{"issue":"3","key":"e_1_2_9_9_1","first-page":"233","article-title":"Dehydration parameters and standards for laboratory mice","volume":"52","author":"Bekkevold C. 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