{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:45:20Z","timestamp":1787730320691,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010038","name":"Earmarked Fund for China Agriculture Research System","doi-asserted-by":"publisher","award":["CARS\u201035"],"award-info":[{"award-number":["CARS\u201035"]}],"id":[{"id":"10.13039\/501100010038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Selenium (Se) is an essential trace element in organism. Se\u00a0deficiency can cause many diseases, including vascular disease. Studies have shown that inflammation is the main inducement of vascular disease, microRNA (miRNA) can influence inflammation in various ways, and Se deficiency can affect miRNAs expression. To study the mechanism of aorta damage caused by Se deficiency, we constructed a Se deficiency porcine aorta model and found that Se deficiency can significantly inhibit miR\u2010223, which downregulates the expression of nucleotide\u2010binding oligomerization domain\u2010like receptor family 3 (NLRP3). Subsequently, we found that in Se\u00a0deficiency group, NLRP3, and its downstream (caspase\u20101, apoptosis\u2010related spot\u2010like protein [ASC], IL\u201018, IL\u20101\u03b2) expression was significantly increased. In vitro, we cultured pig iliac endothelium cell lines, and constructed miR\u2010223 knockdown and overexpression models. NLRP3 messenger RNA and protein levels were significant increased in the knockdown group, and decreased in the overexpression group. The results of this study show that Se\u00a0deficiency in porcine arteries can induce inflammation through miR\u2010223\/NLRP3.<\/jats:p>","DOI":"10.1002\/jcp.30178","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T04:46:04Z","timestamp":1606365964000},"page":"4555-4564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["MicroRNA\u2010223 triggers inflammation in porcine aorta by activating NLRP3 inflammasome under selenium deficiency"],"prefix":"10.1002","volume":"236","author":[{"given":"Zhang","family":"Qing","sequence":"first","affiliation":[{"name":"Department of Basic Veterinary Medicine, College of Veterinary Medicine Northeast Agricultural University  Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Kaixin","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Medicine, College of Veterinary Medicine Northeast Agricultural University  Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Yanfei","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Medicine, College of Veterinary Medicine Northeast Agricultural University  Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Yiming","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Medicine, College of Veterinary Medicine Northeast Agricultural University  Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Hua","sequence":"additional","affiliation":[{"name":"National Selenium\u2010Rich Product Quality Supervision and Inspection Center  Enshi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Ling","sequence":"additional","affiliation":[{"name":"National Selenium\u2010Rich Product Quality Supervision and Inspection Center  Enshi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Guangliang","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Medicine, College of Veterinary Medicine Northeast Agricultural University  Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-5459","authenticated-orcid":false,"given":"Li","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Medicine, College of Veterinary Medicine Northeast Agricultural University  Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02073"},{"key":"e_1_2_10_3_1","article-title":"Selenium plays an anti\u2010inflammatory role by regulation NLRP3 inflammasome in Staphylococcus aureus\u2010infected mouse mammary gland","author":"Bi C. L.","year":"2020","journal-title":"Biological Trace Element Research"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.5.8.2688"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011090"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1725"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9MT00006B"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b01001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.11.008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2014.24"},{"issue":"09","key":"e_1_2_10_11_1","first-page":"114","article-title":"Role and research advances of vascular adventitial inflammation in atherosclerosis","volume":"29","author":"Han S.","year":"2019","journal-title":"Chinese Journal of Comparative Medicine"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394395-8.00001-3"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.6.829"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2004.05.028"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-018-1396-9"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-7-35"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-014-0005-9"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17222"},{"issue":"02","key":"e_1_2_10_19_1","first-page":"83","article-title":"The research progression on the relationship of selenium, iodine, fluorine with Kashin\u2010Beck disease","volume":"33","author":"Liu X.","year":"2012","journal-title":"Foreign\u00a0Medical Sciences (Section of Medgeography)"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.65.5.658"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2527\/2000.7861537x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.390"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-180885"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2000.10718959"},{"issue":"1","key":"e_1_2_10_25_1","first-page":"347","article-title":"miR\u2010126 and miR\u2010223 as biomarkers of vascular damage in the course of chronic kidney disease","volume":"15","author":"Metzinger V.","year":"2014","journal-title":"RNA \uff06 DISEASE"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(02)00143-6"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(00)00189-9"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26794"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-017-0572-3"},{"key":"e_1_2_10_30_1","article-title":"MiR\u2010196\u20105p involvement in selenium deficiency\u2010induced immune damage targeting of NF\u03baBIA in the chicken trachea","author":"Qin L.","year":"2020","journal-title":"Metallomics, 12, 1679\u20131692"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305542200"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.09.002"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(05)80047-8"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2020.02.015"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12458"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2725"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-016-0823-z"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2020.03.047"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.475"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2019.121217"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210293"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.4238\/2015.December.28.19"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.110903"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO00394H"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.01.058"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2014.11.017"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox7050066"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.30178","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.30178","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.30178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T18:48:44Z","timestamp":1693594124000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.30178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,25]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/jcp.30178"],"URL":"https:\/\/doi.org\/10.1002\/jcp.30178","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,25]]},"assertion":[{"value":"2020-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}