{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:45:12Z","timestamp":1784688312580,"version":"3.55.0"},"reference-count":154,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiovascular diseases (CVDs) are the leading cause of death globally and the number of cardiovascular patients, which is estimated to be over 30 million in 2018, represent a challenging issue for the healthcare systems worldwide. Therefore, the identification of novel molecular targets to develop new treatments is an ongoing challenge for the scientific community. In this context, sphingolipids (SLs) have been progressively recognized as potent bioactive compounds that play crucial roles in the modulation of several key biological processes, such as proliferation, differentiation, and apoptosis. Furthermore, SLs involvement in cardiac physiology and pathophysiology attracted much attention, since these molecules could be crucial in the development of CVDs. Among SLs, ceramide and sphingosine\u20101\u2010phosphate (S1P) represent the most studied bioactive lipid mediators, which are characterized by opposing activities in the regulation of the fate of cardiac cells. In particular, maintaining the balance of the so\u2010called ceramide\/S1P rheostat emerged as an important novel therapeutical target to counteract CVDs. Thus, this review aims at critically summarizing the current knowledge about the antithetic roles of ceramide and S1P in cardiomyocytes dysfunctions, highlighting how the modulation of their metabolism through specific molecules, such as myriocin and FTY720, could represent a novel and interesting therapeutic approach to improve the management of CVDs.<\/jats:p>","DOI":"10.1002\/jcp.30235","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T07:02:32Z","timestamp":1610694152000},"page":"4857-4873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The antithetic role of ceramide and sphingosine\u20101\u2010phosphate in cardiac dysfunction"],"prefix":"10.1002","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0196-5977","authenticated-orcid":false,"given":"Federica","family":"Cirillo","sequence":"first","affiliation":[{"name":"Laboratory of Stem Cells for Tissue Engineering IRCCS Policlinico San Donato Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9461-2715","authenticated-orcid":false,"given":"Marco","family":"Piccoli","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells for Tissue Engineering IRCCS Policlinico San Donato Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2896-7390","authenticated-orcid":false,"given":"Andrea","family":"Ghiroldi","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells for Tissue Engineering IRCCS Policlinico San Donato Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3205-2254","authenticated-orcid":false,"given":"Michelle M.","family":"Monasky","sequence":"additional","affiliation":[{"name":"Department of Arrhythmology IRCCS Policlinico San Donato Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5795-4989","authenticated-orcid":false,"given":"Paola","family":"Rota","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1872-9524","authenticated-orcid":false,"given":"Paolo","family":"La Rocca","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences for Health University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1859-130X","authenticated-orcid":false,"given":"Adriana","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells for Tissue Engineering IRCCS Policlinico San Donato Milan Italy"},{"name":"Department of Arrhythmology IRCCS Policlinico San Donato Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1340-9767","authenticated-orcid":false,"given":"Sara","family":"D'Imperio","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells for Tissue Engineering IRCCS Policlinico San Donato Milan Italy"},{"name":"Department of Arrhythmology IRCCS Policlinico San Donato Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2368-2393","authenticated-orcid":false,"given":"Paola","family":"Signorelli","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Biochemistry and Molecular Biology Laboratory University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0901-6135","authenticated-orcid":false,"given":"Carlo","family":"Pappone","sequence":"additional","affiliation":[{"name":"Department of Arrhythmology IRCCS Policlinico San Donato Milan Italy"},{"name":"Faculty of Medicine and Surgery University of Vita\u2010Salute San Raffaele Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-2161","authenticated-orcid":false,"given":"Luigi","family":"Anastasia","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells for Tissue Engineering IRCCS Policlinico San Donato Milan Italy"},{"name":"Faculty of Medicine and Surgery University of Vita\u2010Salute San Raffaele Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406512200"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00638.2003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.10.042"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00946.2010"},{"issue":"1","key":"e_1_2_7_6_1","first-page":"57","article-title":"PPARalpha agonist induces the accumulation of ceramide in the heart of rats fed high\u2010fat diet","volume":"58","author":"Baranowski M.","year":"2007","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109064200"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"issue":"3","key":"e_1_2_7_9_1","first-page":"371","article-title":"Accumulation of specific ceramides in ischemic\/reperfused rat heart; effect of ischemic preconditioning","volume":"53","author":"Beresewicz A.","year":"2002","journal-title":"Journal of Physiology and Pharmacology"},{"issue":"5","key":"e_1_2_7_10_1","first-page":"1257","article-title":"Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion","volume":"151","author":"Bielawska A. E.","year":"1997","journal-title":"American Journal of Pathology"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57144"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R046300"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.7.1612"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00986"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0686"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-005-0035-y"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)37774-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp387"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119664"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002659"},{"issue":"9","key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.3934","article-title":"Nogo\u2010B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure","volume":"21","author":"Cantalupo A.","journal-title":"Nature Medicine"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.11909\/j.issn.1671-5411.2018.05.003"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10947"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.003111"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907839"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-07-2097"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(97)00260-4"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2003.12.016"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/381800a0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1448-3"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2015.10.010"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2005.10.005"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1023\/b:jobb.0000023619.97392.0c"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.9.2105"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00130"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01003.2010"},{"key":"e_1_2_7_37_1","unstructured":"European Cardiovascular Disease Statistics. (2019). Retrieved fromhttps:\/\/ec.europa.eu\/eurostat\/statistics-explained\/pdfscache\/37359.pdf"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2017.03.013"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0336724100"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.11.009"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.17.11369"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6741-1_1"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp056"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.10.6080"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(87)90600-x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01695"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt169"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1072"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00003.2006"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-0650-1_4"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/180705"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2009.01.006"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5294.1855"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2001.1456"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.09.024"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.063586"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600034"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.73.011303.073731"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.08.018"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.96203"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000143632.06471.93"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn065"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.05.029"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01029.2001"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.13450"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909494"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2001.1429"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-010-0125-0"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.5830\/CVJA-2014-016"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2007.12.006"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.6515\/acs20140310a"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.02.019"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2013.10.001"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508382200"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39387-1"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa046"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728220903039722"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700300R"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2002.1533"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.581058"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-00970"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00243"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.319"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002759200"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.000123"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10905"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2020.01.005"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2008.06.002"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1139\/o03-091"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313662200"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14047716"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707422200"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01331.2006"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1043-6618(03)00054-9"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvw004"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr257"},{"issue":"1","key":"e_1_2_7_97_1","first-page":"5","article-title":"Sphingosine\u20101\u2010phosphate: distribution, metabolism and role in the regulation of cellular functions","volume":"85","author":"Morozov V. I.","year":"2013","journal-title":"Ukr Biokhim Zh (1999)"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu378"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8456305"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182329"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01295.2005"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/365557a0"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M800147-JLR200"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.06.005"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1388-1981(02)00335-9"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R600010200"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.81.3.404"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aax8050"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12516"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-016-0533-x"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705510"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2001.1433"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2017.01.002"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63888"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306896200"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513248"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.10.035"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.012427"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-010-0112-5"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00311.2002"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.306842"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.77118"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-014-0445-6"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-012-6376-2"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30335"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.12.8903509"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(00)01670-7"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.1021\/np2000528"},{"key":"e_1_2_7_129_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e328351ab0a"},{"key":"e_1_2_7_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701025"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp312"},{"key":"e_1_2_7_132_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181a7b58a"},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.01.015"},{"key":"e_1_2_7_134_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:GLYC.0000033627.02765.cc"},{"key":"e_1_2_7_135_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.607135"},{"key":"e_1_2_7_136_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000138303.76488.fe"},{"key":"e_1_2_7_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1388-1981(02)00342-6"},{"key":"e_1_2_7_138_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098613481023"},{"key":"e_1_2_7_139_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00358.2009"},{"key":"e_1_2_7_140_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs249"},{"key":"e_1_2_7_141_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-0178"},{"key":"e_1_2_7_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2014.07.008"},{"key":"e_1_2_7_143_1","unstructured":"WHO. (2007).Prevention of cardiovascular disease: guidelines for assessment and management of total cardiovascular risk. Retrieved fromhttp:\/\/www.who.int\/topics\/cardiovascular_diseases\/en\/"},{"key":"e_1_2_7_144_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040741"},{"key":"e_1_2_7_145_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7825"},{"key":"e_1_2_7_146_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16751"},{"key":"e_1_2_7_147_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3325"},{"key":"e_1_2_7_148_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071667"},{"key":"e_1_2_7_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2014.12.007"},{"key":"e_1_2_7_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.12.008"},{"key":"e_1_2_7_151_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003950170057"},{"key":"e_1_2_7_152_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00372.2015"},{"key":"e_1_2_7_153_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00587.2006"},{"key":"e_1_2_7_154_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.85484"},{"key":"e_1_2_7_155_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1784"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.30235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.30235","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.30235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T05:42:58Z","timestamp":1721626978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.30235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,11]]},"references-count":154,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/jcp.30235"],"URL":"https:\/\/doi.org\/10.1002\/jcp.30235","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,11]]},"assertion":[{"value":"2020-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}