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Ferroptosis, a new type of cell death characterized by excessive lipid peroxidation due to the downregulation of GPX4 and system X<jats:sup>c\u2212<\/jats:sup>, is involved in glucocorticoid\u2010induced osteoporosis. Endothelial cell\u2010secreted exosomes (EC\u2010Exos) are important mediators of cell\u2010to\u2010cell communication and are involved in many physiological and pathological processes. However, the effect of EC\u2010Exos on osteoblasts exposed to glucocorticoids has not been reported. Here, we explored the role of EC\u2010Exos in glucocorticoid\u2010induced osteoporosis. In vivo and in vitro experiments indicated that EC\u2010Exos reversed the glucocorticoid\u2010induced osteogenic inhibition of osteoblasts by inhibiting ferritinophagy\u2010dependent ferroptosis.<\/jats:p>","DOI":"10.1002\/jcp.30331","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T04:36:55Z","timestamp":1613709415000},"page":"6691-6705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Exosomes derived from vascular endothelial cells antagonize glucocorticoid\u2010induced osteoporosis by inhibiting ferritinophagy with resultant limited ferroptosis of osteoblasts"],"prefix":"10.1002","volume":"236","author":[{"given":"Run\u2010Ze","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Clinic of Spine Center, Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 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