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Peripheral and central sensitization in painful orofacial processes is common, and it can be triggered by peripheral inflammatory challenge with consequent neuroinflammation phenomena. Such neuroinflammation comes from inflammatory products from supportive cells, blood\u2013brain barrier, and extracellular matrix. Here, we evaluated the possible recruitment of limbic structures for modified matrix metalloproteinases (MMPs) expression and activity during temporomandibular inflammation\u2010induced orofacial persistent pain. The inflammatory process in TMJs of rats was induced by Freund's Complete Adjuvant (CFA) administration. The activity and expression of MMPs\u20102 and 9 were assessed by in situ zymography and conventional zymography, respectively. A glial colocalization with the MMPs was performed using immunofluorescence. The results evidenced both short\u2010 and long\u2010term alterations on MMP\u20102 and \u20109 expression in the limbic structures following CFA\u2010induced temporomandibular inflammation. The gelatinolytic activity was increased in the central amygdala, hippocampus, hypothalamus, ventrolateral periaqueductal gray (vlPAG), superior colliculus, and inferior colliculus. Finally, an increase of colocalization of MMP\u20102\/GFAP and MMP\u20109\/GFAP in CFA\u2010induced inflammation groups was observed when compared with saline groups in the central amygdala and vlPAG. It is possible to suggest that glial activation is partly responsible for the production of gelatinases in the persistent orofacial pain, and it is involved in the initiation and maintenance of this process, indicating that inhibition of MMPs might be pursued as a potential new therapeutic target for TMD.<\/jats:p>","DOI":"10.1002\/jcp.30341","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T17:35:47Z","timestamp":1613928947000},"page":"6571-6580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Temporomandibular inflammation regulates the matrix metalloproteinases MMP\u20102 and MMP\u20109 in limbic structures"],"prefix":"10.1002","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5116-2200","authenticated-orcid":false,"given":"Glauce C.","family":"Nascimento","sequence":"first","affiliation":[{"name":"Department of Psychology, Faculty of Philosophy, Science and Letters of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"},{"name":"Department of Basic and Oral Biology, Ribeir\u00e3o Preto Dentistry Faculty University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna B.","family":"De Paula","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Philosophy, Science and Letters of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel F.","family":"Gerlach","sequence":"additional","affiliation":[{"name":"Department of Basic and Oral Biology, Ribeir\u00e3o Preto Dentistry Faculty University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1762-2730","authenticated-orcid":false,"given":"Christie R. 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