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Atorvastatin has been reported to alleviate early brain injury (EBI) following subarachnoid hemorrhage (SAH) via reducing reactive oxygen species, antiapoptosis, regulated autophagy, and neuroinflammation. Which was the related to the pyroptosis? Pyroptosis can be defined as a highly specific inflammatory programmed cell death, distinct from classical apoptosis and necrosis. However, the precise role of pyroptosis in atorvastatin\u2010mediated neuroprotection following SAH has not been confirmed. The present study aimed to investigate the neuroprotection and potential molecular mechanisms of atorvastatin in the SAH\u2010induced EBI via regulating neural pyroptosis using the filament perforation model of SAH in male C57BL\/6 mice, and the hemin\u2010induced neuron damage model in HT\u201022. Atorvastatin or vehicle was administrated 2\u2009h after SAH and hemin\u2010induced neuron damage. The mortality, neurological score, brain water content, and neuronal death were evaluated. The results show that the atorvastatin treatment markedly increased survival rate, neurological score, greater survival of neurons, downregulated the protein expression of NLRP1, cleaved caspase\u20101, interleukin\u20101\u03b2 (IL\u20101\u03b2), and IL\u201018, which indicated that atorvastatin\u2010inhibited pyroptosis and neuroinflammation, ameliorated neuron death in vivo\/vitro subjected to SAH. Taken together, this study demonstrates that atorvastatin improved the neurological outcome in rats and reduced the neuron death by against neural pyroptosis and neuroinflammation.<\/jats:p>","DOI":"10.1002\/jcp.30351","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T06:28:51Z","timestamp":1617258531000},"page":"6920-6931","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Atorvastatin ameliorates early brain injury after subarachnoid hemorrhage via inhibition of pyroptosis and neuroinflammation"],"prefix":"10.1002","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9410-9722","authenticated-orcid":false,"given":"Junhui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Renmin Hospital of Wuhan University  Wuhan China"},{"name":"Department of Neurosurgery, 904th Hospital of Joint Logistic Support Force of PLA Wuxi Clinical College of Anhui Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, 904th Hospital of Joint Logistic Support Force of PLA Wuxi Clinical College of Anhui Medical University  Wuxi China"},{"name":"Department of Neurosurgery The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfeng","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, 904th Hospital of Joint Logistic Support Force of PLA Wuxi Clinical College of Anhui Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, 904th Hospital of Joint Logistic Support Force of PLA Wuxi Clinical College of Anhui Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, 904th Hospital of Joint Logistic Support Force of PLA Wuxi Clinical College of Anhui Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianxue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.03.032"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2070"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.533315"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001328R"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02097-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102788"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14105"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.280326"},{"issue":"1","key":"e_1_2_10_10_1","first-page":"1651","article-title":"Protective effects of atorvastatin on cerebral vessel autoregulation in an experimental rabbit model of subarachnoid hemorrhage","volume":"17","author":"Chen J. 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