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MicroRNA (miRNA) activity is related to inflammation in OA and some miRNAs specifically regulate IL\u2010mediated degradation of cartilage type II collagen. Previous studies have indicated that miR\u2010144\u20103p is a useful target in the regulation of pro\u2010inflammatory cytokines in different diseases. However, the role of miR\u2010144\u20103p in OA is unclear. In this study, we observed a negative correlation between miR\u2010144\u20103p and IL\u20101\u03b2 expression in OA. miR\u2010144\u20103p mimic transfection of OA synovial fibroblasts downregulated levels of IL\u20101\u03b2 expression, while blocking the MAPK, PI3K\/Akt, and NF\u2010\u03baB signaling pathways relating to IL\u20101\u03b2 production, and effectively increased miR\u2010144\u20103p expression in OASFs. Findings from an anterior cruciate ligament transection rat model revealed that administration of miR\u2010144\u20103p mimic effectively ameliorated OA progression and reduced the numbers of IL\u20101\u03b2\u2010positive cells in synovial tissue. This study suggests that miR\u2010144\u20103p is a useful therapeutic target in OA disease.<\/jats:p>","DOI":"10.1002\/jcp.30361","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T19:00:45Z","timestamp":1616871645000},"page":"6988-7000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["miR\u2010144\u20103p ameliorates the progression of osteoarthritis by targeting IL\u20101\u03b2: Potential therapeutic implications"],"prefix":"10.1002","volume":"236","author":[{"given":"Yen\u2010You","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Medicine China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Yuan","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery China Medical University Hospital  Taichung 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