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Due to their regenerative and reparative properties, MSCs are extremely valuable for cell\u2010based therapy in tackling several pathological conditions including COVID\u201019. Iron is essential for MSC processes but iron\u2010loading, which is common in several chronic conditions, hinders normal MSC functionality. This not only aggravates disease pathology but can also affect allogeneic and autologous MSC therapy. Thus, understanding MSCs from an iron perspective is of clinical significance. Accordingly, this review highlights the roles of iron and iron\u2010related proteins in MSC physiology. It describes the contribution of iron and endogenous iron\u2010related effectors like hepcidin, ferroportin, transferrin receptor, lactoferrin, lipocalin\u20102, bone morphogenetic proteins and hypoxia inducible factors in MSC biology. It summarises the excess\u2010iron\u2010induced alterations in MSC components, processes and discusses signalling pathways involving ROS, PI3K\/AKT, MAPK, p53, AMPK\/MFF\/DRP1 and Wnt. Additionally, it evaluates the endogenous and exogenous saviours of MSCs against iron\u2010toxicity. Lastly, it elaborates on the involvement of MSCs in the pathology of clinical conditions of iron\u2010excess, namely, hereditary hemochromatosis, diabetes, \u03b2\u2010thalassaemia and myelodysplastic syndromes. This unique review integrates the distinct fields of iron regulation and MSC physiology. Through an iron\u2010perspective, it describes both mechanistic and clinical aspects of MSCs and proposes an iron\u2010linked MSC\u2010contribution to physiology, pathology and therapeutics. 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