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Excess iron in the adipose and its roles in dyslipidemia are of interest to be identified. In acute iron overload mice receiving intraperitoneal injection of 100\u2009mg\/kg\/day dextran\u2010iron for 5 days, the epididymis adipose showed a remarkable increase in iron. Serum triglyceride and low\u2010density lipoprotein cholesterol (LDL\u2010C) levels were increased and high\u2010density lipoprotein cholesterol (HDL\u2010C) level was decreased, while serum alkaline phosphatase, aspartate aminotransferase, glucose, and insulin were not affected. The serum\u2010cytokine\u2010microarray showed that adipocytokines, including adiponectin, leptin, and resistin were significantly decreased. Other serum cytokines, including pro\u2010insulin cytokines, inflammatory cytokines, chemokines, and growth factors were not changed, except that ghrelin and chemokine RANTES were increased. Iron overload decreased expressions of adiponectin and leptin both in vivo and in vitro. Intraperitoneal injection of recombinant leptin at 1\u2009\u03bcg\/g in acute iron overload mice had no significant effects on serum levels of TC, TG, HDL\u2010C, and LDL\u2010C, while intraperitoneal injection of recombinant adiponectin at 3\u2009\u03bcg\/g partially restored serum TG level through improving activities of lipoprotein lipase and hepatic lipase, but abnormal serum LDL\u2010C and HDL\u2010C were not redressed, suggesting other mechanisms also existed. In conclusion, the adipose responds to iron overload at an early stage to interfere with lipid metabolism by secreting adipocytokines, which may further affect glucose metabolism, inflammation, and other iron overload\u2010induced effects on the body.<\/jats:p>","DOI":"10.1002\/jcp.30391","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T20:39:29Z","timestamp":1618519169000},"page":"7544-7553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Rapid responses of adipocytes to iron overload increase serum TG level by decreasing adiponectin"],"prefix":"10.1002","volume":"236","author":[{"given":"Yuxiao","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Nutrition Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongyao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of 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