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It was initially identified in cancer research and embryologic developmental studies. Later, the\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    gene was linked to type 2 diabetes (T2D), implicating\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    and Wnt\u2010signaling in metabolic disorders and homeostasis. In fact,\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    \u2010T2D variants confer\u00a0the greatest relative risk for T2D, unquestionably predicting conversion to T2D in individuals with impaired glucose tolerance. We aim to describe the relevance of\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    in other human disorders. The\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    \u2010single nucleotide polymorphisms (SNPs) and T2D\u2010risk association have been replicated in numerous follow\u2010up studies, and research has now been performed in several other diseases. In this article, we discuss common\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    \u2010T2D variants within the framework of their association with human diseases. The\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    functional regions need to be further investigated because the molecular and cellular mechanisms through which\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    contributes to risk associations with different diseases are still not fully elucidated. In this review, we show the association of common\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    \u2010T2D variants with many types of diseases. However, the role of rare genetic variations in the\u00a0\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    gene in distinct diseases and ethnic groups has not been explored, and understanding their impact on specific phenotypes will be of clinical relevance. This offers an excellent opportunity to gain a clearer picture of the role that the\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    gene plays in the pathophysiology of human diseases. The potential pleiotropic role of\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    may underlie a possible pathway for comorbidity in human disorders.\n                  <\/jats:p>","DOI":"10.1002\/jcp.30581","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T11:19:34Z","timestamp":1633691974000},"page":"301-312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["The broad pathogenetic role of\n                    <i>TCF7L2<\/i>\n                    in human diseases beyond type 2 diabetes"],"prefix":"10.1002","volume":"237","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3224-378X","authenticated-orcid":false,"given":"Laura","family":"del Bosque\u2010Plata","sequence":"first","affiliation":[{"name":"Laboratorio de Nutrigen\u00e9tica y Nutrigen\u00f3mica Instituto Nacional de Medicina Gen\u00f3mica  Mexico City 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