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However, whether KYNU contributes to the pathogenesis of psoriasis remains unknown. We sought to investigate the role of KYNU in psoriasis and its possible regulation mechanism. In the results, KYNU is upregulated in psoriatic skin samples from patients or animal models compared with normal skin control which was assayed in psoriatic patient samples, IMQ\u2010induced psoriasis\u2010like skin inflammation in BABL\/c mice and M5\u2010stimulated keratinocyte cell lines by immunohistochemistry (IHC). KYNU knockdown had a trivial impact on keratinocyte proliferation, but significantly inhibited the production of inflammatory cytokines in HaCaT, HEK\u03b1, and HEKn cells by quantitative reverse\u2010transcription polymerase chain reaction, enzyme\u2010linked immunosorbent assay, and western blot analysis. The 3\u02b9\u2010untranslated region of KYNU contains a conserved target site of a skin\u2010specific microRNA (miRNA), miR\u2010203a, as predicted by TargetScan software. Furthermore, miR\u2010203a exhibited an inversed expression kinetics to KYNU during the development of IMQ\u2010induced psoriasis\u2010like skin inflammation in BABL\/c mice. Overexpression of miR\u2010203 subsequently leading to the inhibition of KYNU, could significantly reduce the production of M5\u2010induced, psoriasis\u2010related inflammatory factors in keratinocytes. Finally, KYNU inhibitors could alleviate the pathological phenotypes in IMQ\u2010mice. Our study supported the contributive role of KYNU in the development of psoriasis and provided preliminary evidence for KYNU as a potential therapeutic target in psoriasis.<\/jats:p>","DOI":"10.1002\/jcp.30587","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T05:58:24Z","timestamp":1632376704000},"page":"1044-1056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Kynureninase contributes to the pathogenesis of psoriasis through pro\u2010inflammatory effect"],"prefix":"10.1002","volume":"237","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1934-0158","authenticated-orcid":false,"given":"Min","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital, School of Medicine Xi'an Jiaotong University Xi'an 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