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Islet amyloid is found in the pancreas of patients with type 2 diabetes (T2D) and may be involved in \u03b2\u2010cell dysfunction and death, observed in this disease. Thus, investigating the aspects related to amyloid formation is relevant to the development of strategies towards \u03b2\u2010cell protection. In this sense, IAPP misprocessing, IAPP overproduction, and disturbances in intra\u2010 and extracellular environments seem to be decisive for IAPP to form islet amyloid. Islet amyloid toxicity in \u03b2\u2010cells may be triggered in intra\u2010 and\/or extracellular sites by membrane damage, endoplasmic reticulum stress, autophagy disruption, mitochondrial dysfunction, inflammation, and apoptosis. Importantly, different approaches have been suggested to prevent islet amyloid cytotoxicity, from inhibition of IAPP aggregation to attenuation of cell death mechanisms. Such approaches have improved \u03b2\u2010cell function and prevented the development of hyperglycemia in animals. 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