{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T10:12:20Z","timestamp":1774779140761,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bronchopulmonary dysplasia (BPD) is a chronic lung disease characterized by interrupted alveologenesis and alveolar simplification caused by oxygen therapy in premature infants. Metabolic dysfunction is involved in the pathogenesis of BPD. Fatty acid\u2010binding protein 4 (FABP4) is significantly increased in specific lung tissues in patients with BPD. Therefore, we investigated whether BMS309403, an FABP4 inhibitor that can mitigate tissue fibrosis, can regulate pulmonary fibrotic processes in newborn rats exposed to hyperoxia. Newborn rat pups were exposed to room air (RA; 21% O<jats:sub>2<\/jats:sub>) or 85% O<jats:sub>2<\/jats:sub> from 5 to 14 days of age and were then allowed to recover in RA until 29 days of age. They received intraperitoneal injection with placebo (phosphate\u2010buffered saline [PBS]) or BMS 309403 (0.5\u2009mg or 1.0\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> d<jats:sup>\u22121<\/jats:sup>) every other day from 4 to 14 days of age then were divided into O<jats:sub>2<\/jats:sub> plus PBS or low dose or high dose and RA plus PBS or low dose or high dose groups. We assessed lung histology and evaluated lung collagen I, FABP4 as well as TGF\u2010\u03b21 expression at 14 and 29 days of age. In the hyperoxia injury\u2010recovery model, prophylactic BMS309403 treatment reduced mean linear intercept values and FABP4 expression (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Prophylactic BMS309403 treatment mitigated pulmonary fibrosis and TGF\u2010\u03b21 expression immediately after hyperoxia exposure (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The attenuation of hyperoxia\u2010induced alveolar developmental impairment and pulmonary fibrosis by FABP4 inhibition indicated that such inhibition has potential clinical and therapeutic applications.<\/jats:p>","DOI":"10.1002\/jcp.30622","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T11:40:19Z","timestamp":1635421219000},"page":"1509-1520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Inhibition of FABP4 attenuates hyperoxia\u2010induced lung injury and fibrosis via inhibiting TGF\u2010\u03b2 signaling in neonatal rats"],"prefix":"10.1002","volume":"237","author":[{"given":"Liang\u2010Ti","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Wan Fang Hospital Taipei Medical University Taipei Taiwan"},{"name":"Department of Pediatrics, School of Medicine, College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu\u2010Chu","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, School of Medicine, College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8762-8957","authenticated-orcid":false,"given":"Chung\u2010Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Department of Pediatrics Taipei Medical University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2013.05.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8121507"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201906-1232OC"},{"issue":"8","key":"e_1_2_8_5_1","first-page":"2628","article-title":"Human mesenchymal stem cells attenuate hyperoxia\u2010induced lung injury through inhibition of the renin\u2010angiotensin system in newborn rats","volume":"10","author":"Chen C. 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