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However, the precise mechanism through which apelin\u201013 regulates reticulophagy to participate in cardiomyocyte hypertrophy remains unclear. Herein, we observed that apelin\u201013\u2010induced cardiomyocyte hypertrophy by activating FAM134B\u2010dependent reticulophagy via the Pannexin\u20101\/P2X7 signal pathway. Furthermore, we found that apelin\u201013 stimulated the opening of Pannexin\u20101 hemichannel and increased extracellular ATP (eATP) levels, which activated the P2X7 purinergic receptor. Activation of the Pannexin\u20101\/eATP\/P2X7 axis subsequently led to FAM134B\u2010dependent reticulophagy. Moreover, inhibition of the Pannexin\u20101\/P2X7 axis and FAM134B\u2010dependent reticulophagy reversed apelin\u201013\u2010induced cardiomyocyte hypertrophy. Based on our present findings, apelin\u201013\/APJ induces cardiomyocyte hypertrophy by activating the Pannexin\u20101\/P2X7 axis and FAM134B\u2010dependent reticulophagy.<\/jats:p>","DOI":"10.1002\/jcp.30685","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T05:04:16Z","timestamp":1644210256000},"page":"2230-2248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Apelin\u201013\/APJ induces cardiomyocyte hypertrophy by activating the Pannexin\u20101\/P2X7 axis and FAM134B\u2010dependent reticulophagy"],"prefix":"10.1002","volume":"237","author":[{"given":"Yiyuan","family":"Yang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Science Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study University of South China 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