{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:48:05Z","timestamp":1779313685001,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T00:00:00Z","timestamp":1648339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801238"],"award-info":[{"award-number":["81801238"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neural precursor cells (NPCs) generate new neurons to supplement neuronal loss as well as to repair damaged neural circuits. Therefore, NPCs have potential applications in a variety of neurological diseases, such as spinal cord injury, traumatic brain injury, and glaucoma. Specifically, improving NPCs proliferation and manipulating their differentiated cell types can be a beneficial therapy for a variety of these diseases. ADT\u2010OH is a slow\u2010releasing organic H<jats:sub>2<\/jats:sub>S donor that produces a slow and continuous release of H<jats:sub>2<\/jats:sub>S to maintain normal brain functions. In this study, we aimed to explore the effect of ADT\u2010OH on NPCs. Our results demonstrated that ADT\u2010OH promotes self\u2010renewal and antiapoptosis ability of cultured NPCs. Additionally, it facilitates more NPCs to differentiate into neurons and oligodendrocytes, while inhibiting their differentiation into astrocytes. Furthermore, it enhances axonal growth. Moreover, we discovered that the mRNA and protein expression of \u03b2\u2010catenin, TCF7L2, c\u2010Myc, Ngn1, and Ngn2, which are key genes that regulate NPCs self\u2010renewal and differentiation, were increased in the presence of ADT\u2010OH. Altogether, these results indicate that ADT\u2010OH may be a promising drug to regulate the neurogenesis of NPCs, and needs to be studied in the future for clinical application potential.<\/jats:p>","DOI":"10.1002\/jcp.30726","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T04:29:15Z","timestamp":1648441755000},"page":"2877-2887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Role of the hydrogen sulfide\u2010releasing donor ADT\u2010OH in the regulation of mammal neural precursor cells"],"prefix":"10.1002","volume":"237","author":[{"given":"Shan\u2010Wen","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Soochow University, Orthopedic Institute Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Ming","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Huan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Affiliated Suzhou Science &amp; Technology Town Hospital of Nanjing Medical University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation The Affiliated Zhangjiagang Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng\u2010Fei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei\u2010Hong","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Medical Technology Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation The Affiliated Zhangjiagang Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8930-0274","authenticated-orcid":false,"given":"Yan\u2010Xia","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Soochow University, Orthopedic Institute Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0166-2236(00)01716-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012030268"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709002105"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(00)80781-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","unstructured":"Cantile C. &Youssef S.(2016).Nervous System(pp.250\u2013406).Jubb Kennedy & Palmer's Pathology of Domestic Animals.https:\/\/doi.org\/10.1016\/b978-0-7020-5317-7.00004-7","DOI":"10.1016\/B978-0-7020-5317-7.00004-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074192"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.09.018"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082134"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705891104"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.09.037"},{"key":"e_1_2_8_12_1","unstructured":"Fang F. 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