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The level of CD38 expression in B cells has become an important factor in the clinical diagnosis, treatment, and prognosis of malignant tumors and other related diseases. Therefore, studying the relationship between CD38 expression on the surface of B cells and the occurrence of the disease is of great significance for elucidating its association with disease pathogenesis and the clinical targeted therapy. In this paper, we review the effects of CD38 on B\u2010cell activation, proliferation, and differentiation, and elaborate the functional role and mechanism of CD38 expression on B cells. We also summarize the relationship between the level of CD38 expression on the surface of B cells and the diagnosis, treatment, and prognosis of various diseases, as well as the potential use of targeted CD38 treatment for related diseases. This will provide an important theoretical basis for the scientific research and clinical diagnosis and treatment of B\u2010cell\u2010related diseases.<\/jats:p>","DOI":"10.1002\/jcp.30760","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T16:18:47Z","timestamp":1651249127000},"page":"2796-2807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Effect of CD38 on B\u2010cell function and its role in the diagnosis and treatment of B\u2010cell\u2010related diseases"],"prefix":"10.1002","volume":"237","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3297-1528","authenticated-orcid":false,"given":"Feng","family":"Zeng","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha Hunan China"},{"name":"Cancer Research Institute, Basic School of 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