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Acute myocardial infarction, stress ulcer, pancreatitis, intestinal ischemia, intermittent claudication, acute tubular necrosis, postshock liver failure, and multisystem organ failure are all related to reperfusion injury. AMP\u2010activated protein kinase (AMPK) has been identified in multiple catabolic and anabolic signaling pathways. The functions of AMPK during health and diseases are intriguing but still need further research. Except for its conventional roles as an intracellular energy switch, emerging evidence reveals the critical role of AMPK in IRI as an energy\u2010sensing signal molecule by regulating metabolism, autophagy, oxidative stress, inflammation, and other progressions. At the same time, drugs based on AMPK for the treatment of IRI are constantly being researched and applied in clinics. In this review, we summarize the mechanisms underlying the effects of AMPK in IRI and describe the AMPK\u2010targeting drugs in treatment, hoping to increase the understanding of AMPK in IRI and provide new insights into future clinical treatment.<\/jats:p>","DOI":"10.1002\/jcp.30875","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T08:59:37Z","timestamp":1663837177000},"page":"4079-4096","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["AMPK: The\u00a0key to ischemia\u2010reperfusion injury"],"prefix":"10.1002","volume":"237","author":[{"given":"Jie","family":"Cai","sequence":"first","affiliation":[{"name":"The Second Clinical Medical College of Nanchang University, The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi 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