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As an RP, RPS27a assembles into ribosomes, but it also functions independently of ribosomes. RPS27a is involved in the development and poor prognosis of various cancers, such as colorectal cancer, liver cancer, chronic myeloid leukemia, and renal carcinoma, and is associated with poor prognosis. Notably, the murine double minute 2\/P53 axis is a major pathway through which RPS27a regulates cancer development. Moreover, RPS27a maintains sperm motility, regulates winged aphid indirect flight muscle\u00a0degeneration, and facilitates plant growth. Additionally, RPS27a is a metalloprotein and mercury (Hg) biomarker. In the present review, we described the origin, structure, and biological functions of RPS27a.<\/jats:p>","DOI":"10.1002\/jcp.30941","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T13:10:26Z","timestamp":1672319426000},"page":"485-497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Multifaceted functions of RPS27a: An unconventional ribosomal protein"],"prefix":"10.1002","volume":"238","author":[{"given":"Jingshun","family":"Luo","sequence":"first","affiliation":[{"name":"Key Laboratory of Cardiovascular Diseases of Yunnan Province, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province Central laboratory of Yan'an Hospital Affiliated to Kunming Medical University  Kunming Yunnan China"},{"name":"Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative 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