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Besides the attempts for an optimal recovery of knee function after surgery, the joint healing process is not always adequate given the nature of intra\u2010articular environment. Based on that, different therapeutic methods attempt to improve healing capacity. Hyperbaric oxygen therapy (HBOT) is an innovative biophysical approach that can be used as an adjuvant treatment post\u2010knee surgery, to potentially prevent chronic disorders that commonly follows knee injuries. Given the well\u2010recognized role of HBOT in improving wound healing, further research is necessary to clarify the benefits of HBOT in damaged musculoskeletal tissues, especially knee disorders. Here, we review important mechanisms of action for HBOT\u2010induced healing including the induction of angiogenesis, modulation of inflammation and extracellular matrix components, and activation of parenchyma cells\u2014key events to restore knee function after injury. This review discusses the basic science of the healing process in knee injuries, the role of oxygen during cicatrization, and shed light on the promising actions of HBOT in treating knee disorders, such as tendon, ligament, and cartilage injuries.<\/jats:p>","DOI":"10.1002\/jcp.30947","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T18:41:05Z","timestamp":1673980865000},"page":"498-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Revisiting the role of hyperbaric oxygen therapy in knee injuries: Potential benefits and mechanisms"],"prefix":"10.1002","volume":"238","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8386-3121","authenticated-orcid":false,"given":"Chilan B.\u00a0G.","family":"Leite","sequence":"first","affiliation":[{"name":"Instituto de Ortopedia e Traumatologia, Hospital das Clinicas, HCFMUSP, Faculdade de Medicina Universidade de Sao Paulo Sao Paulo Brazil"},{"name":"Department of Orthopedic Surgery, Center for Cartilage Repair and Sports Medicine, Harvard Medical School Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana P.","family":"Tavares","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care Medicine,\u00a0Harvard Medical School Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magno S.","family":"Leite","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Polui\u00e7\u00e3o Atmosf\u00e9rica Experimental LIM05, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina Universidade de S\u00e3o Paulo (USP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco K.","family":"Demange","sequence":"additional","affiliation":[{"name":"Instituto de Ortopedia e Traumatologia, Hospital das Clinicas, HCFMUSP, Faculdade de Medicina Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X11399172"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/982794"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.22462\/07.08.2018.5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4137\/CMAMD.S22147"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000258979.92828.bc"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000225430.42531.c2"},{"issue":"3","key":"e_1_2_9_8_1","first-page":"181","article-title":"Effects of hyperbaric oxygen and platelet derived growth factor on medial collateral ligament fibroblasts","volume":"34","author":"Chan Y. 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