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During this process, the balance between bone absorption mediated by osteoclasts and bone formation mediated by osteoblasts is damaged. Consistent with previous studies, we observed that depletion of cylindromatosis (CYLD) resulted in an osteoporotic bone phenotype. However, the effect of CYLD deficiency on periodontitis is undetermined. Here, we investigated whether CYLD affects periodontal tissue homeostasis in experimental periodontitis in <jats:italic>Cyld<\/jats:italic> knockout (KO) mice, and we explored the underlying mechanisms. Interestingly, we discovered significant alveolar bone density loss and severely reduced alveolar bone height in <jats:italic>Cyld<\/jats:italic> KO mice with experimentally induced periodontitis. We observed increased osteoclast number and activity in both the femurs and alveolar bones, accompanied by the downregulation of osteogenesis genes and upregulation of osteoclastogenesis genes of alveolar bones in ligatured <jats:italic>Cyld<\/jats:italic> KO mice. Taken together, our findings demonstrate that the deletion of CYLD in mice plays a vital role in the pathogenesis of periodontal bone loss and suggest that CYLD might exert an ameliorative effect on periodontal inflammatory responses.<\/jats:p>","DOI":"10.1002\/jcp.30990","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T05:37:06Z","timestamp":1678945026000},"page":"1036-1045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["CYLD inhibits osteoclastogenesis to ameliorate alveolar bone loss in mice with periodontitis"],"prefix":"10.1002","volume":"238","author":[{"given":"Yuxin","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Endodontics and Laboratory of Stem Cells Endocrine Immunology Tianjin Medical University School of Stomatology Tianjin 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