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To explore the molecular mechanisms driving the growth and progression of DLBCL, we analyzed genes with differential expression in DLBCL using the Gene Expression Profiling Interactive Analysis database. <jats:italic>Enkurin domain\u2010containing protein 1<\/jats:italic> (<jats:italic>ENKD1<\/jats:italic>), a centrosomal protein\u2010encoding gene, was found to be highly expressed in DLBCL samples compared with normal samples. The phylogenetic analysis revealed that <jats:italic>ENKD1<\/jats:italic> is evolutionarily conserved. Depletion of ENKD1 in cultured DLBCL cells induced apoptosis, suppressed cell proliferation, and blocked cell cycle progression in the G2\/M phase. Moreover, <jats:italic>ENKD1<\/jats:italic> expression positively correlates with the expression levels of a number of cellular homeostatic regulators, including <jats:italic>Sperm\u2010associated antigen 5<\/jats:italic>, a gene encoding an important mitotic regulator. These findings thus demonstrate a critical function for ENKD1 in regulating the cellular homeostasis and suggest a potential value of targeting ENKD1 for the treatment of DLBCL.<\/jats:p>","DOI":"10.1002\/jcp.31012","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T08:59:31Z","timestamp":1679648371000},"page":"1308-1323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Upregulation of ENKD1 disrupts cellular homeostasis to promote lymphoma development"],"prefix":"10.1002","volume":"238","author":[{"given":"Ting","family":"Song","sequence":"first","affiliation":[{"name":"Department of Cell Biology, School of Basic Medical Sciences, Cheeloo Medical College Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqian","family":"Hao","sequence":"additional","affiliation":[{"name":"College of Artificial Intelligence and Big Data for Medical Sciences, Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5266-7208","authenticated-orcid":false,"given":"Yunfan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, School of Basic Medical Sciences, Cheeloo Medical College Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2021.0531"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)32407-2"},{"key":"e_1_2_8_5_1","first-page":"28","article-title":"Fitting a mixture model by expectation maximization to discover motifs in biopolymers","volume":"2","author":"Bailey T. 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