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The Notch is an evolutionary conserved developmental signaling pathway, with critical roles in embryonic development by controlling cell proliferation and differentiation. However, the Notch pathway is also critically involved in cancer initiation and progression, such as osteosarcoma, leukemia, and multiple myeloma. The Notch\u2010mediated malignant cells dysregulate bone and bone marrow cells in the tumour microenvironment, resulting in disorders ranging from osteoporosis to bone marrow dysfunction. To date, the complex interplay of Notch signaling molecules in hematopoietic and bone stromal cells is still poorly understood. In this mini\u2010review, we summarize the crosstalk between cells in bone and bone marrow and their influence under the Notch signaling pathway in physiological conditions and in tumour microenvironment.<\/jats:p>","DOI":"10.1002\/jcp.31042","type":"journal-article","created":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T17:39:47Z","timestamp":1685813987000},"page":"1478-1491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Osteohematology: To be or Notch to be"],"prefix":"10.1002","volume":"238","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1957-930X","authenticated-orcid":false,"given":"Emel","family":"Rothzerg","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences The University of Western Australia  Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy N.","family":"Erber","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences The University of Western Australia  Nedlands Western Australia Australia"},{"name":"PathWest Laboratory Medicine  Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L. 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